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Endocarditis and Inflammatory Diseases

Colchicine for Prevention of Postpericardiotomy Syndrome and Postoperative Atrial Fibrillation
September 7, 2014
The COPPS-2 trial evaluated the efficacy of oral colchicine in reducing a-fib, post-pericardiotomy syndrome, and pericardial/pleural effusion after cardiac surgery in 360 pts randomized to drug or placebo for 1 month postop.  Colchicine reduced the incidence of post-pericardiotomy syndrome (20% vs 30%) but had no important effect on effusions or a-fi
Outcomes and Prosthesis Choice for Active Aortic Valve Infective Endocarditis: Analysis of The Society of Thoracic Surgeons Adult Cardiac Surgery Database
September 4, 2014
This study summarized data regarding valve use in over 1l,000 pts in the STS database who underwent aortic valve replacement for active endocarditis.  Nearly 75% of pts had no prior cardiac surgery.  Prior cardiac surgery was associated with a higher risk of root replacement (29.9% vs 7.2%), a higher rate of complications (68% vs 61%), and a substant
Surgery for infective endocarditis complicated by cerebral embolism: A consecutive series of 375 patients
June 16, 2014
The rate of cerebral embolism in patients with acute infective endocarditis (AIE) was about one quarter on CT scanning, with about one third having silent emboli. This had an adverse impact on survival. Haemorrhagic transformation was low. The authors indicate CT scanning should be routine for all patients with AIE.
Infective endocarditis: Perioperative management and surgical principles
March 26, 2014
This comprehensive review discusses evolving strategies for managing infective endocarditis and the mechanisms for how the most common and life-threatening complications occur.

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