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Heart Failure

February 2, 2016
This randomized trial (NEAT-HFpEF) of 110 subjects (59 placebos) disproves, by clinical and biological markers, the utility of nitrates for exercise tolerance.  This is a subset of cardiac failure patients we are likely to encounter in general cardiothoracic surgical practice.
January 9, 2016
The authors performed a randomized control study of 178 patients with heart failure and systolic dyssynchrony who were accepted for CABG, randomizing the participants into two groups:  CABG alone (n=87) and CABG + concomitant epicardial CRT (n=91).  CRT was activated postoperatively.
November 5, 2015
This is a very intersting case review in which the authors describe a successful heart transplant from a 37 year old donor on VV ECMO to a 62 year old female recipeint. The authors postulate that this successful outcome may expand the available donor pool for heart transplantation.
September 4, 2015
Changes in risk profile and outcomes over 40 years were assessed from the Stanford experience with heart transplant in children.  Age at transplant decreased in the most recent time period from about 10 to 5.6 years.  The use of mechnical support as bridge increased dramatically over the time of the study.  Long-term survival increased dramatically,
August 14, 2015
The Texas Heart Institute reports its experience with 27 patients with prior continuous flow LVADs who had undergone varying degrees of device explantation.  Although the numbers are small, the explantation methods ranged from near-complete device removal to driveline transection and removal.
August 12, 2015
A single institution retrospectively reviewed the correlation of preoperative serum albumin level with outcomes after LVAD implantation from 2006 to 2014.  A lower albumin level was associated with a significant increase in postop renal failure and prolonged hospitalization, but not overall short-term and long-term survival.
August 6, 2015
This retrospective analysis of the BTT continuous flow (CF) LVAD experience from Harefield Hospital addresses the question: "What are the predictors of the requirement for an RVAD at the time of LVAD implantation?" Of the 152 patients included in the study, 23% underwent RVAD implantation.
May 17, 2015
The question of whether digoxin increases the risk of death in patients with atrial fibrillation (AF) or congestive heart failure (CHF) continues to be a matter of debate. The authors of this manuscript attempt to find an answer with a meta-analysis and systematic review of the literature.
May 10, 2015
This is a follow up study by the investigators on aortic valve opening during continuous flow LVAD support. Their earlier study looked at the rate of aortic insufficiency during CF LVAD support therapy comparing patients who achieved aortic valve opening during rest versus those who did not.
April 9, 2015
This concensus statement reviews the unique physiology, insertion techniques, and clinical indications for use of percutaneous mechanical circulatory support devices.  As the options for management of different etiologies of heart failure in adult and pediatric populations expand, understanding the advantages of specific devices is vital. 

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