This consensus effort provides a new definition for septic shock, which affects a subset of patients with sepsis. The definition requires the presence of circulatory disturbances (BP unresponsive to fluids and requiring pressors), cellular and metabolic abnormalities (serum lactate level >2 mmol/L). The presence of these criteria is associated
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Blood Transfusion and 30-Day Mortality in Patients With Coronary Artery Disease and Anemia Following Noncardiac Surgery
February 18, 2016
The authors studied the relationship of outcomes after non-cardiac surgery to blood transfusion among over 7,300 patients. Patients with significant bleeding were excluded. Patients were stratified according to the occurence of postoperative MI and the nadir hematocrit value (20-24%, 24-27%, 27-30%). The outcome was 30-day mortality. In the no-
Clinical Characteristics and Outcomes of Patients With Myocardial Infarction and Cardiogenic Shock Undergoing Coronary Artery Bypass Surgery: Data From The Society of Thoracic Surgeons National Database
January 30, 2016
Outcomes of CABG for patients in cardiogenic shock after acute MI were evaluated using data from the STS Database. The study group of nearly 5,500 patients comprised 1.5% of all CABG patients during the study period. Operative mortality was 18.7%. Mechanical circulatory support use was most common in patients with more risk factors or high clinica
December 27, 2015
The authors tested a group of 176 patients undergoing cardiac surgery for dysphagia both preoperatively and postoperatively. Preoperatively, 8.5% of patients failed the swallow test. Postoperatively, 21.6% failed the test. All patients who failed preoperatively also failed postoperatively.
November 16, 2015
Data from a large multicenter registry were evaluated to determine whether there is a sex difference in susceptibility to acute kidney injury after CBP related to nadir hematocrit levels. Based on a 21% hematocrit threshold, 9.5% of men and 31.9% of women were affected. Rates of AKI were similar between the sexes. There was a strong interaction be
September 4, 2015
This study from the Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative evaluated outcomes of CABG in 33 hospitals 2011-2013, assessing the association of blood transfusion (39.9% of pts) and the incidence of postoperative pneumonia (3.6% of pts). Blood transfusion was associated with an increased risk of pneumonia (OR 3.
Randomized Phase II Study of the Anti-inflammatory Effect of Ghrelin During the Postoperative Period of Esophagectomy
July 14, 2015
This small randomized trial evaluated the potential benefits of ghrelin, an anti-inflammatory agent, in reducing the SIRS response after esophagectomy. The ghrelin group had a reduced SIRS duration, lower CRP levels, and lower IL-6 levels compared to controls. Pulmonary complications were reduced in the ghrelin group, but other complication inciden
Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury
July 6, 2015
This is a provocative study questioning the current practice of using blood pressure targets perioperatively to ensure adequate perfusion. Plasma levels of a brain-specific injury biomarker (GFAP) were measured in 121 patients undergoing cardiac surgery.
Insights into the problem of alarm fatigue with physiologic monitor devices: a comprehensive observational study of consecutive intensive care unit patients
April 8, 2015
This thought provoking article by Drew et al., utilized state-of-the art monitoring technology to document the problem of "alarm fatigue" by recording an astounding number of alarm events; 2,558,760 unique alarms were triggered for 461 patients over a 31-day period.
April 8, 2015
The authors describe a simplified method of providing regional citrate anticoagulation for Continuous Renal Replacement Therapy (CRRT) to patients.