Patient Care and General Interest
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Lung Cancer - Molecular Markers
In Global News: Cardiac Regeneration in Pigs, Health Effects of Marijuana Use, and Running to Reduce Aortic Stiffness
May 10, 2019
May 31, 2018
This randomized trial evaluating the relative efficacy of immunotherapy and chemotherapy in patients with recurrent or metastatic disease, immunotherapy was associated with significantly better progression-free survival. Tumor mutational burden was a marker for patient selection for immunotherapy.
May 30, 2018
The addition of pembrolizumab (targeting PD-1) to standard chemotherapy substantially improved time to progression and overall survival compared to chemotherapy alone in patients with metastatic lung cancer.
May 23, 2018
This is among the first and largest summaries of the use of neoadjuvant PD-1 inhibitor (nivolumab) in patients with resectable lung cancer. The safety profile was adequate, 20 of 21 patients underwent complete resection, and the pathologic major response rate was 45%. The response was similar regardless of PD-L1 status, and response was related to
December 13, 2017
Liquid biopsies have long held promise for diagnosis, treatment selection, and surveillance of lung cancer patients. This articles summarizes results of two studies involving highly precise measurement of tumor mutational burden. A burden of 16-fold or greater was associated with improved overall survival with immunotherapy (atezolizumab) compared
Serum Biomarkers May Prognosticate Recurrence in Node-Negative, Non-Small Cell Lung Cancers Less Than 4 Centimeters
October 31, 2017
In this single institution study, the authors screened biorepository materials obtained from patients undergoing resection for early stage cancer. They wished to identify serum markers related to early recurrence. A 7-component panel was developed that had a negative predictive value of 83% and an accuracy of 78%. The accuracy was 70%.
October 24, 2017
A useful reminder of the substantial progress that has been made and the continuing challenges that we face in fighting this terrible disease.
August 2, 2017
This is an excellent summary of progress during the past year in all aspects of lung cancer, from prevention/detection through molecular therapies and future perspectives. Each section is written by a handful of international experts.
Tracking the Evolution of Non-Small-Cell Lung Cancer- a DNA test that is 90% sensitive to detect recurrence up to a year before CT
May 8, 2017
Researchers conducted a study, published in Nature, to investigate whether this genetic diversity could be tracked clinically.
September 27, 2016
The authors assessed the relationship between second hand smoke exposure in non-smokers and mortality related to lung cancer using serum cotinine levels. Cotinine levels were associated with survival, death from lung cancer, and death from all cancers after adjustment. Such levels identify second hand smoke effects.