Trials evaluating the use of surgery in stage IIIB NSCLC are lacking. This study goes some way to address that and demonstrates that surgery as part of multi-modality therapy may result in a survival benefit.
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Lung Cancer - Surgery
June 14, 2015
June 12, 2015
This meta-analysis of published studies evaluated outcomes of multimodality therapy including resection for superior sulcus NSCLC invading the spine. 134 articles were evaluated, which included 135 patients. 63% had induction therapy, and all underwent en bloc resection. 52% had adjuvant therapy. Survival at 3,5, and 10 years was 57%, 42%, and 27
May 22, 2015
In this retrospective review of 336 patients treated surgically for early stage NSCLC, the prognostic value of PET SUV was evaluated. Risks of recurrence and death increased steadily as SUV increased.
April 2, 2015
The authors retrospectively reviewed their institutional database to assess outcomes for VATS lobectomy vs SBRT for stage I NSCLC, comparing propensity score-matched groups (41 pairs). Survival, cancer-specific survival, local recurrence, and distant recurrence were significantly better in the surgical group.
February 21, 2015
Indications for postoperative radiation therapy (PORT) for resected lung cancer are unclear. This study evaluated outcomes from the National Cancer Data Base 2004-2006, including 2115 patients resected with pathologic N2 NSCLC, of whom 918 (43%) received PORT. PORT was associated with better median survival (42 vs 38 mos, p=0.048) and was associat
February 16, 2015
This trial randomized 61 pts to a program of endurance and strength training or no training beginning 5-7 weeks after lung resection for cancer and lasting 20 weeks. Compared to controls, treatment group patients demonstrated significant improvements in peak O2 uptake, DLCO, leg and arm strength, muscle mass, and QOL.
February 3, 2015
This consensus statement from the European Neuroendocrine Society is based on extensive bibliographic searches and systematic review. Surgery is the mainstay of therapy for most tumors, and includes resection of metastases when this can be accomplished in a curative manner. Somatostatin analogues are considered first line therapy for unresectable c
February 2, 2015
The authors queried the National Cancer Data Base to assess outcomes of patients with R1 resection margins related to the presence and type of postoperative adjuvant therapy. 3.1% of over 54,000 resections had R1 margins, which negatively affected long-term survival. Combined chemotherapy and radiation therapy improved outcomes; administration of c
February 2, 2015
This study propensity-score matched patients from a cohort who underwent resection for stage I or II lung cancer and compared 175 pairs who underwent VATS or open lobectomy. The VATS group experienced shorter hospital length of stay, fewer complications, and more frequent discharge to home. Survival was similar.
January 29, 2015
This meta-analysis of 6 prior publications analyzed factors associated with outcomes after resection of synchronous lung cancers. Favorable predictors of survival were exclusive adenocarcinoma, small T size, bilateral disease, no nodal involvement, young age, and female sex.