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Pharmacology

September 13, 2021
A brief but dense editorial included in a compedium on cardioplegia. The last sentence summarises what many colleagues would think on the matter of single-shot plegia for root surgery.    
February 21, 2021
An editorial that may herald the decrease in aspirinization and the rise of ticagrelor monotherapy in Percutaneous stenting of coronary arteries.
January 30, 2021
A Canadian multi-centre RCT of immediate baloon-cryoablation of the pulmonary veins: the intervention was compared to the relevant standard of pharmacological care. The target population was treatment-naive sufferers of de novo paroxysmal atrial fibrillation.
January 16, 2021
A recent European consensus paper. Relatively easily read, and favouring meta-analyses over randomised trials. The bulk of the manuscript is of interest to all healthcare providers. The chapters 2.8.1 and 3.1.2 are of additional relevance to the ctsnet readership, as they summarise guidance on interventions.
November 28, 2020
A large RCT with results somewhat supportive of considering a NOAC in the place of warfarin for post operative surgical patients. The study will be weighed against healthcare economical aspects.
November 21, 2020
A scholarly and sober narrative review on , as the authors state,  a ' hot topic' that is already being debated in Multidisciplinary Meetings and Lung Cnacer Boards.
November 17, 2020
A latge RCT of the first myosin inhibitor in severe chronic heart failure: somewhat difficult to interpret results, as deaths were slightly higher in the intervention group while there was no 'significant' benefit in cardiovascular deaths.
October 1, 2020
Death from cardiovascular causes, stroke, or hospitalization with worsening of heart failure or acute coronary syndrome was reduced (P=0.005) by early pharmacogical or inteventional ablation for fast response-atrial fibrillation in a small German RCT. 
September 15, 2020
An open-access large metanalysis on the utility and risks of antiplatelets after PCI. Of note, mortality was not a primary endpoint. The message is that long dual antiplatelet use is an exchange between avoidance of myocardial events and serious bleeding. The novel oral anticoagulants may enter the arena soon..
August 18, 2020
A review that may affect pharma strategy in the immediate future.

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