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Cancer

November 10, 2014
Joel Dunning talks with Douglas Wood about key aspects of general thoracic surgery and the importance of specialization for the future of the specialty in a interview recorded at the 2014 EACTS Annual Meeting.
November 5, 2014
The authors examined cost-effectiveness in the National Lung Screening Trial (NLST), examining incremental cost-effectiveness ratio (ICER) and quality-adjusted life years (QALYs) associated with low dose CT screening.  The ICER was $52,000 per life-year gained and the $81,000 per QALY gained.  These values were very sensitive to variations in the scr
November 5, 2014
Long-term QOL outcomes were assessed in a single institution cohort of 63 patients undergoing colon interposition after esophagectomy.  48% of pts had a vagal sparing operation, and resection was performed for cancer in the majority of the pts.  Followup median was 13 yrs.  Mean SF36 scores were above the published average and GI QOL was 3 out of 4. 
November 5, 2014
The potential benefit of wedge resection vs anatomic resection for stage I and II lung cancer was examined using propensity score matching for pts from the STS Database.  Over 3700 pts were matched in each group.  Wedge resection was associated with fewer major complications (4.5% vs 9.0%) and lower mortality (1.2% vs 1.9%).  Wedge resection reduced
October 16, 2014
Because of the observation that already debilitated pts who undergo lung resection become even more debilitated afterwards, the authors conducted a randomized trial of endurance and strength training for 20 wks after major lung resection.  Training significantly improved peak VO2, DLCO, strength, endurance, and muscle mass compared to controls.  Qual
October 15, 2014
It seems that patients with lung or colorectal cancer have poor enrollment in clinical trials, according to the recent multiregional survey carried out by the authors in a cohort of 8778 patients three to six months after diagnosis. Only 14% of patients have discussed their participation in clinical trials.
October 15, 2014
Using a data set of over 76,000 women from the Women's Health Initiative Observational Study, the effects of active and passive smoking on cancer were evaluated.  Lung cancer incidence was highest among active smokers (HR 13.44) and was also high among prior smokers (HR 4.20).  A prolonged exposure (>30 yr) to passive smoking in the household also
October 14, 2014
Lung cancer cases 2000-2013 in the UK Health Improvement Network were evaluated for factors associated with early death (within 90 days of diagnosis) vs later death.  Risk factors for early death included male sex, older age, current smoking, social deprivation, and rural location.  Those experiencing early death saw their primary care physicians mor
October 8, 2014
This multicenter prospective trial evaluated the impact of induction therapy on anastomotic leak (AL) and other complications after esophagectomy.  Of 2944 included pts, 593 had induction chemoradiotherapy.  AL occurred in 8.8% of induction therapy pts compared to 10.6% of surgery only patients.  90 day postoperative morbidity and mortality rates wer
October 8, 2014
The authors investigated the impact of new onset a-fib after esophagectomy in 437 pts.  Risk factors included age, diabetes, induction therapy, and cardiac history.  A-fib was associated with postoperative pneumonia, symptomatic pleural effusions, and an increase in C-reactive protein.  It was not associated with anastomotic leak or mortality.  92% o

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