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Association of NSAID Use With Risk of Bleeding and Cardiovascular Events in Patients Receiving Antithrombotic Therapy After Myocardial Infarction
This study evaluated potential safety concerns of using NSAIDS in combination with antithrombotic agents 30 days or more after MI. The population studied was comprised of nearly 62,000 Danish patients. Use of NSAIDs at any time doubled the risk of a bleeding episode and increased the risk of a major cardiovascular event by 40%. The NSAIDs risks were present even after short-term NSAIDS use.