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Concordance Between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens
The authors demonstrated substantial concordance between sequencing of 39 genes in a liquid assay and routine diagnostic testing in tissue in 82 patients. Agreement was 98%, and the primary reason for failure was low levels of circulating DNA in the plasma. Sensitivity was 70%, and specificity was 100%. The system offers accurate identification of driver mutations in plasma of patients with NSCLC.