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Durvalumab After Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer

Monday, February 5, 2018

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Source Name: New England Journal of Medicine


Scott J. Antonia, Augusto Villegas, Davey Daniel, David Vicente, Shuji Murakami, Rina Hui, Takashi Yokoi, Alberto Chiappori, Ki H. Lee, Maike de Wit, Byoung C. Cho, Maryam Bourhaba, Xavier Quantin, Takaaki Tokito, Tarek Mekhail, David Planchard, Young-Chul Kim, Christos S. Karapetis, Sandrine Hiret, Gyula Ostoros, Kaoru Kubota, Jhanelle E. Gray, Luis Paz-Ares, Javier de Castro Carpeño, Catherine Wadsworth, Giovanni Melillo, Haiyi Jiang, Yifan Huang, Phillip A. Dennis, and Mustafa Özgüroğlu, for the PACIFIC Investigators

This randomized trial compared chemoradiotherapy alone to chemoradiotherapy followed by consolidation therapy with the PDL-1 antibody durvalumab in patients with stage III NSCLC.  The treatment group had significantly improved progression-free survival, response rate, and overall survival, with clinically meaningful differences between the groups.  The findings suggest that such regimens may be the new standard of care in these patients.


This is practice changing for inoperable stage 3 lung cancer.

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