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Is Epinephrine During Cardiac Arrest Associated With Worse Outcomes in Resuscitated Patients?

Wednesday, December 3, 2014

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Source Name: Journal of the American College of Cardiology


Florence Dumas; Wulfran Bougouin; Guillaume Geri; Lionel Lamhaut; Adrien Bougle; Fabrice Daviaud; Tristan Morichau-Beauchant; Julien Rosencher; Eloi Marijon; Pierre Carli; Xavier Jouven; Thomas D. Rea; Alain Cariou

This study determined the relationship of pre-hospital use of epinephrine during resuscitation to survival in patients who experienced return of spontaneous circulation after out of hospital cardiac arrest. 73% received epinephrine, and 17% of those patients experienced a good outcome (discharged alive with good neurologic status).  Of those who did not received epinephrine, 63% had a good outcome.  There was a dose-response effect.  Delayed administration of epinephrine had the worst outcomes. 

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