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The Impact of Severe Anastomotic Leak on Long-term Survival and Cancer Recurrence After Surgical Resection for Esophageal Malignancy

Wednesday, November 11, 2015

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Markar, Sheraz; Gronnier, Caroline; Duhamel, Alain; Mabrut, Jean-Yves; Bail, Jean-Pierre; Carrere, Nicolas; Lefevre, Jérémie H.; Brigand, Cécile; Vaillant, Jean-Christophe; Adham, Mustapha; Msika, Simon; Demartines, Nicolas; Nakadi, Issam El; Meunier, Bernard; Collet, Denis; Mariette, Christophe; on behalf of the FREGAT (French Eso-Gastric Tumors) working group, FRENCH (Fédération de Recherche EN CHirurgie), and AFC (Association Française de Chirurgie)

A French multicenter database was used to assess the relationship between severe anastomotic leak on outcomes after esophagectomy.  Among 2439 pts, 8.5% developed a severe leak.  This was associated with lower median overall survival (36 mos vs 55 mos) and disease-free survival (34 mos vs 48 mos), a 28% increased likelihood of death, and a significant increase in recurrence.

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