This site is not optimized for Internet Explorer 8 (or older).

Please upgrade to a newer version of Internet Explorer or use an alternate browser such as Chrome or Firefox.

Increased Variance in Oral and Gastric Microbiome Correlates With Esophagectomy Anastomotic Leak

Tuesday, March 13, 2018

Submitted by


Source Name: The Annals of Thoracic Surgery


Rishindra M. Reddy, William B. Weir, Shari Barnett, Brendan T. Heiden, Mark B. Orringer, Jules Lin, Andrew C. Chang, Philip W. Carrott, William R. Lynch, David G. Beer, J. Christopher Fenno, Yvonne Kapila

Reddy and colleagues evaluated oral, esophageal, and gastric microbial flora in 55 patients who underwent successful esophagectomy for adenocarcinoma, squamous cell carcinoma, or benign disease. The authors did not observe significant patterns between microbiome diversity and tumor stage or histology. Patients who had anastomotic leak, however, showed a greater variance in the composition of preoperative oral flora versus intraoperative gastric flora than patients who did not (p = 0.015). The authors suggest that better understanding of the relationship between the microbiome and esophagectomy recovery could lead to new predictive or therapeutic approaches for esophageal anastomotic leak.

Add comment

Log in or register to post comments