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Intraoperative Molecular Imaging Combined With Positron Emission Tomography Improves Surgical Management of Peripheral Malignant Pulmonary Nodules

Friday, August 11, 2017

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Predina, Jarrod D.; Newton, Andrew D.; Keating, Jane; Barbosa, Eduardo M. Jr.; Okusanya, Olugbenga; Xia, Leilei; Dunbar, Ashley; Connolly, Courtney; Baldassari, Michael P.; Mizelle, Jack; Delikatny, Edward J.; Kucharczuk, John C.; Deshpande, Charuhas; Kularatne, Sumith A.; Low, Phillip; Drebin, Jeffrey; Singhal, Sunil

This prospective study evaluated whether intraoperative molecular imaging (IMI) with a folate receptor targeted contrast agent visible in the near-infrared spectrum improved the detection of peripheral malignant lung nodules.  Fifty patients undergoing surgery for peripheral nodules had a preoperative PET scan and were imaged intraoperatively.   IMI identified 95% of nodules and 9 additional lesions not seen preoperatively.  IMI sensitivity was greater than that of PET (96% vs 74%) and had a greater positive predictive value (94% vs 89%).  IMI improved management in 30% of patients.

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