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Long-term Outcomes of Heart Transplantation in Adults With Univentricular Versus Biventricular Congenital Heart Disease

Tuesday, March 19, 2024

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Source Name: European Journal of Cardio-Thoracic Surgery


Nabil Dib, Laurence Iserin, Shaida Varnous, Romain Guillemain, Sebastien Hascoet, Emre Belli, Sarah Cohen

Heart transplantation (HT) is the only life extending option in adults with congenital heart disease (CHD) and end stage heart failure. This study evaluated outcomes after heart transplantation in adults with univentricular versus biventricular CHD. One-hundred-forty-nine patients were included, 55 of whom (36.9 percent) had univentricular CHD. Follow up was for a mean of 10.1 years. Sixty-four patients died during follow up, including 47 before discharge from hospital. Multivariable analysis showed univentricular physiology (odds ratio (OR) 2.99, 95 percent CI 1.33–6.74) and female recipient gender (OR 2.76, 95 percent CI 1.23–6.74) carried higher risk of early mortality. For patients who survived the early period, long-term survival was excellent and did not differ between the groups.

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