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Preoperative Sildenafil administration in children undergoing cardiac surgery: a randomized controlled preconditioning study

Friday, May 6, 2016

Submitted by

CTSNet Staff

Source

Source Name: Eur J Cardiothorac Surg

Source URL: http://ejcts.oxfordjournals.org/content/49/5/1403.abstract

Author(s)

Varsha Walavalkar, Egmond Evers, Suresh Pujar, Kiran Viralam, Shreesha Maiya, Stefan Frerich, Colin John, Shekhar Rao, Chinnaswamy Reddy, Bart Spronck, Frits W. Prinzen, Tammo Delhaas, and Ward Y. Vanagt

The effectivity of Sildenafil for preoperative preconditioning in pediatric heart surgery was tested in a randomized trial. Thirteen children each with low-dose (0.06 mg/kg), high-dose (0.6 mg/kg) or no preconditioning underwent VSD closure. Sildenafil application did not alter myocardial injury, cardiac function, inotropic needs or postoperative course.