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Role of Omega-6 Fatty Acid Metabolism in Cardiac Surgery Postoperative Bleeding Risk

Thursday, October 13, 2022

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Velho, Tiago R. MD; Ferreira, Ricardo MD; Willmann, Katharina PhD; Pedroso, Dora PhD; Paixão, Tiago PhD; Pereira, Rafael Maniés CLP; Junqueira, Nádia MD; Guerra, Nuno Carvalho MD; Brito, Dulce PhD; Almeida, Ana G. PhD; Nobre, Ângelo MD; Köcher, Thomas PhD; Pinto, Fausto PhD; Moita, Luís Ferreira PhD

Postoperative bleeding in patients undergoing cardiac surgery is a frequent problem, and this study aimed to test the contribution of metabolic perturbations to platelet dysfunction after cardiac surgery. Patients undergoing elective surgical aortic valve replacement were included in the study. The results suggested that preoperative levels of arachidonic acid may be more relevant than platelet count to anticipate and prevent postoperative blood loss in these patients.

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