Survival and Recurrence of Endocarditis Following Mechanical Versus Biological Aortic Valve Replacement for Endocarditis in Patients Aged 40 to 65 Years: Data From the INFECT-Registry

Overall, 4,365 patients were diagnosed and operated on for infective endocarditis (IE) from 2000 to 2021. Long-term survival was significantly higher among patients receiving a mechanical prosthesis than those receiving a biological prosthesis (hazard ratio [HR] 0.546, 95 percent CI: 0.322-0.926, p= 0.025). Mechanical prostheses were associated with significantly less recurrent endocarditis after AVR than biological prostheses (HR 0.268, 95 percent CI: 0.077-0.933, p= 0.039). The present analysis of the INFECT-REGISTRY shows increased survival and reduced recurrence of endocarditis after a mechanical aortic valve prosthesis implant for IE in middle-aged patients.