This site is not optimized for Internet Explorer 8 (or older).
Please upgrade to a newer version of Internet Explorer or use an alternate browser such as Chrome or Firefox.
Transcatheter Versus Surgical Aortic Valve Replacement in Patients at Low Surgical Risk: A Meta-Analysis of Randomized Trials and Propensity Score Matched Observational Studies
In this meta-analysis, the authors compare surgical aortic valve replacement (SAVR) with transcatheter aortic valve implantation (TAVI) in patients at low surgical risk. They included two randomized controlled trials and four propensity-matched studies for a total of almost 3500 patients. Short term mortality was similar between treatments, but intermediate follow-up (two years) showed higher mortality with TAVI versus SAVR (17.2% versus 12.7%, p=0.006).
Although these results should be taken with caution due to the largely non-randomized nature, it proves that we need to await the results of the currently ongoing low-risk trials (NOTION 2, PARTNER 3, and Medtronic TAVI low-risk trial) before we can recommend TAVI in low-risk patients.