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Tumor Spread through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas

Thursday, April 23, 2015

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Source Name: Journal of Thoracic Oncology


Kadota, Kyuichi; Nitadori, Jun-ichi; Sima, Camelia S.; Ujiie, Hideki; Rizk, Nabil P.; Jones, David R.; Adusumilli, Prasad S.; Travis, William D.

The authors reviewed patients with small resected stage I lung adenocarcinoma to determine the frequency of tumor cells spreading through airway spaces (STAS) and their relationship to recurrent cancer. Nearly 40% of patients had tumor cells in the airways beyond the edge of the main tumor.  In patients undergoing parenchymal-sparing operations, the recurrence rate was much higher in patients with tumor STAS (43% vs 11%).  This relationship was not identified in patients undergoing lobectomy.  Tumor STAS should be recognized as a pattern of invasive spread among patients with lung adenocarcinoma.

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