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Utility of GERAADA Score for Predicting Long-Term Survival Following Surgical Repair of Aortic Dissection

Thursday, October 2, 2025

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Source

Source Name: Interdisciplinary CardioVascular and Thoracic Surgery

Author(s)

Francesco Pollari, Paolo Nardi, Elisa Mikus, Francesco Ferraro, Marco Gemelli, Ilaria Franzese, Ilaria Chirichilli, Claudia Romagnoni, Giuseppe Santarpino, Salvatore Nicolardi, Roberto Scrofani, Federico Ranocchi, Enzo Mazzaro, Gino Gerosa, Massimo Massetti, Carlo Savini, Giovanni Ruvolo, Luca Di Marco, Oriana D'Ecclesiis, Emma Guagneli, Giorgia Duranti, Alessandro Parolari, Fabio Barili, GIROC (Italian Research Group on Outcome in Cardiac Surgery)

The article aimed to assess the long-term survival outcomes following surgical repair in patients with type A aortic dissection (ATAAD) and to evaluate the correlation with the preoperative German Registry for Acute Type A Aortic Dissection (GERAADA)-score value. The authors enrolled patients from nine hospitals. Follow-up information was obtained by matching the clinical patient data with a national administrative database. A total of 1,110 patients were analyzed. The median age was 67 years (IQR 57–75), and females comprised 30.8 percent of the cohort. The median GERAADA score was 14.3 percent (10.2–22]). The mean length of follow-up was 4.19 years. Discrimination was poor but remained stable over time (AUC at 1-year follow-up: 0.66; 95 percent CI 0.63–0.70; AUC at 10-year follow-up: 0.64; 95 percent CI 0.61–0.68). Calibration plots showed under-prediction until a 50 percent predicted probability and progressive over-prediction afterward. There was a steep mortality rate in the first couple of months after surgery, while afterward, the mortality rate was constantly lower. The GERAADA-score was found to be a predictor of long-term mortality with a nonlinear association. 

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