Women With Chronic Coronary Artery Disease: Long-Term Outcomes After Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting

This propensity score-matched cohort study compared long-term outcomes of percutaneous coronary intervention (PCI) vs coronary artery bypass grafting (CABG) in 2,033 matched pairs of women with chronic severe coronary artery disease. The mean age was 66.5 years, with a median follow-up of 5.1 years. PCI was associated with a significantly higher risk of major adverse cardiovascular and cerebral events (MACCE) compared with CABG (hazard ratio [HR] 1.81). All-cause mortality was also higher after PCI (HR 1.34), as was cardiovascular readmission for myocardial infarction, heart failure, or stroke (HR 1.40). These real-world data show a consistent long-term survival and event-free advantage for CABG over PCI in women with severe chronic coronary artery disease (CAD), supporting CABG as the preferred revascularization strategy in this context.