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Cancer

May 29, 2014
This multicenter retrospective review included 518 pts from 9 centers who underwent EPP from 2000 to 2010.  Half the pts received induction chemotherapy, and nearly three-quarters of the patients received postoperative adjuvant therapy, primarily chemotherapy.  The major surgical complication rate was 26% and 90 day mortality was 6.9%.  3-year surviv
May 28, 2014
  Extracapsular spread of cancer cells is associated with poorer outcome compared to intracapsular limitation in positive lymphnodes in patients with adenocarcinoma of the oesophagus and gastro-oesophageal junction. This finding is not reflected by the current tumour staging system.  
May 27, 2014
This metanalysis identified 26 eligible studies that assess the predictive value of PET for survival after induction therapy.  Complete metabolic response was associated with a 50% decrease in mortality and in tumor recurrence compared to no response.   
May 27, 2014
This retrospective single institution review assessed the incidence of hiatal hernia after minimally invasive esophagectomy (MIE).  Of 114 patients followed, 9 (8%) developed herniation, of whom 5 were symptomatic.  All were repaired laparoscopically, except 2 who underwent emergent surgery, with good results.
May 22, 2014
David Sugarbaker, Director of the International Mesothelioma Program, discusses the use of extrapleural pneumonectomy in the treatment of mesothelioma.
May 21, 2014
Pts undergoing salvage esophagectomy after definitive chemoradiotherapy were evaluated for perdictors of survival.  5-year survival was 30%, which was related to tumor recurrence rather than residual tumor, complete resection, N status, M status, and dissection of more than 15 nodes.  Additional neck dissection was not found to provide additional ben
May 21, 2014
This study evaluated over 200 RTCs of systemic therapy for NSCLC.  There has been a steady increase in the number of trials reporting outcomes for progression-free survival.  Over 50% of trials now report a positive outcome without meeting the primary endpoint of the trial.  Although the sample size of the trials is increasing, the magnitude of repor
May 21, 2014
The PORTICO trial has opened to evaluate the Portico Transcatheter Aortic Valve System.  This prospective multicenter trial involving up to 40 sites will randomize pts to Portico vs another TAVR valve in the US. 
May 15, 2014
Betty Tong, Co-Director of the Lung Cancer Screening Program at Duke University Medical Center, discusses the process of establishing a lung cancer screening program.
May 9, 2014
Using the Nationwide Inpatient Sample, the authors evaluated outcomes and costs of VATS (37,595) vs robotic (2,498) lobectomy 2008-2011.  Robotic lobectomy was associated with higher rates of complications, particularly cardiovascular and iatrogenic bleeding, and higher costs ($22,582 vs $17,874).

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