A succinct editorial from a British academic transplant surgeon. It discusses the need for stratifying the utilization of donor lungs based on recent and previous retrospective papers from North American and European databases. Professor Dark also briefly debates the needs for research on assessing and optimizing the organs.
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Unilateral chronic lung allograft dysfunction is a characteristic of bilateral living-donor lobar lung transplantation
September 17, 2015
This single-center study analyses outcomes of living-donor lobar lung transplantations. Eight out of 38 patients who survived more than three months developed chronic lung allograft dysfunction (CLAD). Six of these eight patients had undergone bilateral transplantation.
Association Between Prolonged Graft Ischemia and Primary Graft Failure or Survival Following Lung Transplantation
June 18, 2015
Using UNOS data, the authors evaluated long-term survival and primary graft failure (PGF) comparing cohorts with less than and more than 6 hours of graft ischemia. 31% of patients had prolonged ischemia. There was no association between prolonged ischemia and PGF or survival at 1 and 5 years.
Single- vs Double-Lung Transplantation in Patients With Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis Since the Implementation of Lung Allocation Based on Medical Need
March 3, 2015
The impact of the new Lung Allocation Score (implemented in 2005) on outcomes of single and double lung transplants for IPF and COPD was explored. After controlling for confounders with propensity score techniques, DLT was associated with better graft survival for IPF but there was no difference in graft survival between DLT and SLT for COPD patient
March 2, 2015
This study evaluated outcomes of synchronous or delayed kidney Tx in patients with lung or heart-lung transplant. Delayed living-donor kidney Tx was associated with favorable outcomes. Synchronous cadaver kidney transplant at the time of heart-lung or lung transplant was clinically challenging.
January 26, 2015
In this retrospective study of 173 lung transplants performed at Loyola University, investigators found a correlation between heavy alcohol use in lung transplant donors and risk of developing severe primary graft dysfunction. Those recipients had an 8.7 times higher risk than patients who received lungs from donors who did not drink.
Balloon Atrial Septostomy in Pulmonary Arterial Hypertension: Effect on Survival and Associated Outcomes
January 24, 2015
The Columbia group performed a retrospective analysis of 46 balloon atrial septostomies in 32 patients with severe and medically refractory PAH from 2002-2013. There were no procedural deaths or complications. BAS was safely used as a bridge to lung transplantation or to alleviate right heart failure symptoms and/or syncope.
Incidence and severity of primary graft dysfunction after lung transplantation using rejected grafts reconditioned with ex vivo lung perfusion
November 2, 2014
Ex-vivo lung reperfusion was employed to recondition marginal or rejected lung grafts. Eight out of 11 lungs were deemed suitable for transplantation after treatment. Results with regard to primary graft dysfunction were comparable to those of 28 regular transplantations.
Extended recipients but not extended donors are associated with poor outcomes following lung transplantation
May 28, 2014
Outcomes in lung transplantation after previous lung volume reduction surgery in a contemporary cohort
May 6, 2014
Outcomes of patients undergoing lung transplant after LVRS were compared to those of patients undergoing LVRS or transplant alone. OR time and LOS were longer in the combined group. Morbidity and mortality were similar among the groups. Post-transplant survival was substantially lower in the combined group. However, if time from LVRS to transplan