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Changes in Pulmonary Function Following Image-Guided Stereotactic Lung Radiotherapy

Monday, December 28, 2015

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Source

Source Name: Journal of Thoracic Oncology

Author(s)

Brandon Stone, Victor S. Mangona, Matthew D. Johnson, Hong Ye, and Inga S. Grills

The goal of this study was to present the changes in pulmonary function after SBRT in 127 patients with clinical stage I NSCLC or a single lung metastasis. These patients were either too high risk for an operation or preferred a non-operative treatment approach. PFTs were measured at several time points including within 10 weeks of starting SBRT and then 6 weeks, 3 months, 6 months, 9 months, 1 year and 2 years after treatment (median follow-up was 25 months). At 12 months, there were significant decreases in TLC (-3.6%), FVC (-5.7%), FVC % predicted (-4.6%), FEV1 (-4.1%), and corrected DLCO (-5.2%) compared to baseline. At 24 months, there were significant decreases in FVC (-8.9%), and FEV1 (-7.6%) compared to baseline. When compared to surgical series, the reductions in lung function appear later and are smaller.  

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