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Five-Year Outcomes With PCI Guided by Fractional Flow Reserve
Over 1200 patients with stable coronary artery disease and at least one angiographically-significant stenosis were randomized to percutaneous coronary intervention (PCI) plus medical therapy or medical therapy alone for lesions with fractional flow reserve (FFR) <0.8. FFR-guided PCI was associated with a significantly reduced composite outcome (death, myocardial infarction, or urgent revascularization). Patients without hemodynamically significant lesions had good outcomes on medical therapy alone.