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Prognostic Value of Twist, Snail and E-cadherin Expression in Pathological N0 Non-Small-Cell Lung Cancer: A Retrospective Cohort Study

Monday, August 13, 2018

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Source Name: European Journal of Cardio-Thoracic Surgery


Guanghui Wang, Wei Ma, Yun Li, Yuanzhu Jiang, Guoyuan Ma, Xiangwei Zhang, Long Meng, Jiajun Du

The 5-year survival rate in patients after curative surgery for N0 nonsmall cell lung cancer (NSCLC) is reduced by recurrence and metastasis, and there is evidence that the epithelial–mesenchymal transition in cancer cells is associated with metastasis. Wang and colleagues analyzed the expression of epithelial–mesenchymal transition regulators Twist and Snail, and their target E‑cadherin, in resected tissue from 78 patients diagnosed with pathological N0 NSCLC. They found that high expression of Twist and Snail and low expression of E-cadherin were associated with worse recurrence-free survival.

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