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Regeneration of Severely Damaged Lungs Using an Interventional Cross-Circulation Platform

Wednesday, May 29, 2019

Submitted by

Mark Ferguson

Source

Source Name: Nature Communications

Source URL: https://www.nature.com/articles/s41467-019-09908-1

Author(s)

Brandon A. Guenthart, John D. O’Neill, Jinho Kim, Dawn Queen, Scott Chicotka, Kenmond Fung, Michael Simpson, Rachel Donocoff, Michael Salna, Charles C. Marboe, Katherine Cunningham, Susan P. Halligan, Holly M. Wobma, Ahmed E. Hozain, Alexander Romanov, Gordana Vunjak-Novakovic, Matthew Bacchetta

A common cause of donor lung unsuitability is aspiration pneumonitis. Pig lungs experimentally damaged by aspiration of gastric contents were supported using cross-circulation with a living swine donor, resulting in cellular regeneration and substantial recovery.