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Journal and News Scan
This 5-year follow-up of the first tissue engineered airway using decellularized human trachea demonstrated that the graft became well vascularized, had normal ciliary function and mucous clearance, and maintained a normal diameter. no anti-donor antibodies developed. The graft replaced the left main bronchus that was affected by tracheomalacia. The proximal anastomosis developed stenosis requiring stenting.
The FDA approved the CoreValve TAVI device for use in the US. The approval was originally expected to occur in April 2014, but the panel decided that an independent review of data from the clinical study of extreme-risk patients in the CoreValve US Pivotal Trial was not needed at this time.
The authors studied over 5,700 pts undergoing CABG to assess the dynamics of changes in renal function and related such changes to mortality. Perioperative renal dysfunction was associated with increased long-term mortality. Recovery from renal dysfunction was associated with some improvement in long-term mortality risk. Alternative methods of classifying renal dysfunction may be more useful than creatinine in assessing long-term risk.