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Journal and News Scan

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): S Wang, Y Tachimori, H IGaki, H Nakazato, T Kishino

Pts undergoing salvage esophagectomy after definitive chemoradiotherapy were evaluated for perdictors of survival.  5-year survival was 30%, which was related to tumor recurrence rather than residual tumor, complete resection, N status, M status, and dissection of more than 15 nodes.  Additional neck dissection was not found to provide additional benefit.

Source: Journal of Clinical Oncology
Author(s): AG Sacher, LW Le, NB Leighl

This study evaluated over 200 RTCs of systemic therapy for NSCLC.  There has been a steady increase in the number of trials reporting outcomes for progression-free survival.  Over 50% of trials now report a positive outcome without meeting the primary endpoint of the trial.  Although the sample size of the trials is increasing, the magnitude of reported survival gain is decreasing (now 2.5 mos).

Source: St. Jude Medical
Author(s): St. Jude Medical

The PORTICO trial has opened to evaluate the Portico Transcatheter Aortic Valve System.  This prospective multicenter trial involving up to 40 sites will randomize pts to Portico vs another TAVR valve in the US. 

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): S Taghavi, SN Jayarajan, E Komaroff, AA Mangi

The influence of continuous flow LVAD devices on heart transplant was examined using UNOS data, comparing outcomes of cfLVAD to pulsatile flow LVAD (pfLVAD) and no LVAD pts.   cfLVAD pts spent longer time on the waitlist and were status IA for longer than either of the other groups.  Waitlist survival was better for the cfLVAD pts.  Post-transplant survival was similar among the 3 groups. 

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): H Gutermann, M Pettinari, C Van Kerrebroek, M Vander Laenen, K Engelen, T Fret, RA Dion

The authors present results of surgery in 12 pts for hypertrophic cardiomyopathy extending to the papillary muscles.  Repair was performed through a detached anterior mitral leaflet, which was subsequently repaired.  The intraventricular end-diastolic gradient was decreased by 80% postop, and mitral regurgitation that was present preop was eliminated.  One patient died, the others were in NYHA class I or II postop. 

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): A Della Corte and others for the International Bicuspid Aortic Valve Consotium (BAVCon) Investigators

This expert review identifies knowledge gaps with regards to valvulopathy and aortopathy associated with bicuspid valves and proposes strategies for improving knowledge.

Source: Journal of interventional Cardiology
Author(s): Yang L, et al.

The researchers performed a systematic review to look at outcomes and complications associated with transcatheter closure of ventricular septal defects (VSD). This analysis suggests that transcatheter device closure of VSD is safe and yields good results. The limitations of this study are difficulties in analyzing different devices individually, and segregating the different VSD types, Further stratification by type of VSD, age of patients, and prevention of complications is needed before this can be recommended for routine treatment.


  • A PubMed search for series in English on device closure of VSD from 2003 to June 2012 was performed.
  • They excluded small series that were included in multicenter studies and patients who had acquired VSD following myocardial infarction.
  • The random effects model was used to obtain pooled estimates of success and complications.


  • A total of 37 publications comprising 4,406 patients with VSD (perimembranous=3,758, muscular=419, intracristal=47, doubly committed subarterial=36, multiple=16, postsurgical=123, unclassified=7) were included in this analysis.
  • The age of patients ranged from 3 days to 84 years.
  • The pooled estimate of successful device implantation was 96.6% (95% CI: 95.7-97.5).
  • The most common complication is residual shunt (pooled estimated 25.5%; 95% CI: 18.9-32.1).
  • Others included valvular defects (pooled estimate 4.9%; 95% CI: 3.4–6.4) and arrhythmias (pooled estimate 10.6%; 95% CI: 8.4-12.7).
Source: Journal of the American Medical Association
Author(s): Richard D. Semba, MD,; Luigi Ferrucci, MD, PhD; Benedetta Bartali, PhD; Mireia Urpí-Sarda, PhD; Raul Zamora-Ros, PhD; Kai Sun, MS; Antonio Cherubini, MD, PhD; Stefania Bandinelli, MD; Cristina Andres-Lacueva, PhD

We are all dissapointed to see that a study that looked at 783 patients from the chianti region over 10 years that looked at resveratrol metabolites showed no health benefits for high intake of this mtabolite of chocolate and wine  

Source: Chest
Author(s): Subroto Paul; Jessica Jalbert; Abby J. Isaacs; Nasser K. Altorki; O. Wayne Isom; Art Sedrakyan

Using the Nationwide Inpatient Sample, the authors evaluated outcomes and costs of VATS (37,595) vs robotic (2,498) lobectomy 2008-2011.  Robotic lobectomy was associated with higher rates of complications, particularly cardiovascular and iatrogenic bleeding, and higher costs ($22,582 vs $17,874).

Source: Heart
Author(s): Bernard Iung, Cédric Laouénan, Dominique Himbert, Hélène Eltchaninoff, Karine Chevreul, Patrick Donzeau-Gouge, Jean Fajadet, Pascal Leprince, Alain Leguerrier, Michel Lièvre, Alain Prat, Emmanuel Teiger, Marc Laskar, Alec Vahanian, Martine Gilard, for the FRANCE 2 Investigators

The FRANCE  2 investigators have developed a scoring system to predict the risk of in-hospital or 30-day mortality for patients undergoing TAVI. There were 3833 TAVIs used for  development and validation of the scoring system with the majority of patients receiving an Edwards Sapien prosthesis. Risk factors for early mortality included age greater than or equal to 90, BMI greater than 30, NYHA class IV, pulmonary hypertension, critical haemodynamic state, more than 2 episodes of pulmonary oedema in the first year, respiratory insufficiency, dialysis and implantation route other than subclavian. The developed 21-point scoring system only demonstrated average discriminatory ability.