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Journal and News Scan
In this paper, the authors aim to further understand the factors associated with vein graft failure (VGF) after CABG. They used data on 1828 participants in the PREVENT IV trial to identify patient and surgical factors associated with VGF. They found that longer surgical duration, endoscopic vein harvesting, poor target artery quality and postoperative clopidogrel use were independently associated with VGF. These findings will help identifying patients at high risk of VGF, as well as helping to develop interventions with lower rates of VGF.
In this manuscript, the authors use meta-analysis techniques to evaluate the relationship between measured coronary fractional flow reserve (FFR) and patients’ outcomes. They demonstrate that FFR provides a continuous and independent marker of subsequent MACE as modulated by treatment (medical therapy vs revascularization) in a broad range of clinical scenarios. Lesions with lower FFR values receive larger absolute benefits from PCI or CABG. When FFR values are high, we can do harm by proceeding with revascularization. The cut-point for determining revascularization strategy using this statistical analysis remains in the 0.75-0.80 range, which is in keeping with previous reports on this subject. According to the findings, the authors conclude that an FFR-guided revascularization strategy significantly reduces MACE and increases freedom from angina with less PCI or CABG than an anatomy-based strategy.
In a retrospective cohort study of patients less than 18 years old who underwent cardiopulmonary bypass, intraoperative hemodynamics and vasopressor use were compared between patients who received preoperative ACE inhibitor/ARB therapy and those who did not. Use of preoperative ACE inhibitors and ARBs in pediatric patients undergoing cardiac surgery did not increase the incidence of hypotension after induction of anesthesia and did not increase vasoconstrictor requirements upon weaning from cardiopulmonary bypass.
Because of the observation that already debilitated pts who undergo lung resection become even more debilitated afterwards, the authors conducted a randomized trial of endurance and strength training for 20 wks after major lung resection. Training significantly improved peak VO2, DLCO, strength, endurance, and muscle mass compared to controls. Quality of life, both physical and mental, was also improved with the training compared to controls.
In the last EACTS meeting celebrated in Milan, presented by A. Kerr nee Bradley and colleagues from Birmingham Heartlands Hospital, are the first data in humans showing the improvement in chest wall motion in both operated and contralateral sides following diaphragmatic plication for unilateral paralysis.
It seems that patients with lung or colorectal cancer have poor enrollment in clinical trials, according to the recent multiregional survey carried out by the authors in a cohort of 8778 patients three to six months after diagnosis. Only 14% of patients have discussed their participation in clinical trials.
Using a data set of over 76,000 women from the Women's Health Initiative Observational Study, the effects of active and passive smoking on cancer were evaluated. Lung cancer incidence was highest among active smokers (HR 13.44) and was also high among prior smokers (HR 4.20). A prolonged exposure (>30 yr) to passive smoking in the household also increased the risk of lung cancer (HR 1.61).
More than minimally manipulated (MMM) allograft heart valves should be classified as high risk devices, requiring premarket approval including safety and efficacy studies, according to an FDA panel.
This multicenter observational study evaluated midterm outcomes after use of the lung volume reduction endobronchial coil for severe emphysema in 60 pts. The 30-day complication rate was moderate. At 12 mos, the St. George's Respiratory Questionnaire decreased by 11.1 points, 6 min walk distance increased by 51.4 m, FEV1 increased by 0.11 L, and residual volume decreased by 0.71 L.
Lung cancer cases 2000-2013 in the UK Health Improvement Network were evaluated for factors associated with early death (within 90 days of diagnosis) vs later death. Risk factors for early death included male sex, older age, current smoking, social deprivation, and rural location. Those experiencing early death saw their primary care physicians more frequently prior to diagnosis, possibly representing missed opportunities to make an earlier diagnosis.