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Journal and News Scan

Source: Journal of the National Cancer Institute
Author(s): MS Shiels, RM Pfeiffer, A Hildesheim, EA Engels, TJ Kemp, J-H Park, HA Katki, J Koshiol, G Shelton, NE Caporaso, LA Pinto, AK Chaturvedi

A case-control study within a large screening trial was performed to evaluate the relationship of serum inflammation markers and lung cancer.  Of 68 evaluable markers, 11 were found to have a significant association with lung cancer.  Increasing marker levels were associated with increasing cancer risk. The findings were unrelated to cell type and smoking status.

Source: American Journal of Cardiology
Author(s): Conrotto F, D'Ascenzo F, Giordana F, Salizzoni S, Tamburino C, Tarantini G, Presbitero P, Barbanti M, Gasparetto V, Mennuni M, Napodano M, Rossi ML, La Torre M, Ferraro G, Omedè P, Scacciatella P, Marra WG, Colaci C, Biondi-Zoccai G, Moretti C, D'Amico M,Rinaldi M, Gaita F, Marra S.

In this manuscript the authors evaluate the data from an Italian multicentre registry looking at the effect of diabetes mellitus (DM) on outcomes following transcatheter aortic valve implantations. At 30 days, patients with orally treated and insulin-treated DM demonstrated non-significant higher rates of all cause and cardiovascular death than non-diabetic patients. There was no difference with regards to safety outcomes such as acute kidney injury, vascular complications, stroke or life-threatening bleeding, between diabetic and non-diabetic patients.
Ad midterm follow up (median 400 days), and after multivariable analysis, insulin-treated DM was independently correlated with death and myocardial infarction.

Source: Test
Source: Thorax
Author(s): R Bhatnagar, ED Reid, JP Corcoran, JD Bagenal, S Pope, AO Clive, N Zahan-Evans, PO Froeschle, D West, NM Rahman, S Chatterji, PR Sivasothy, NA Maskell

This multcenter UK review identified 57 patients who underwent indwelling pleural catheter (IPC) insertion for benign causes, primarily hepatic hydrothorax and non-infectious pleuritis.  Infection occurred in 3.5% and successful pleurodesis was achieved in 33% at a median of 71 days.  Hepatic hydrothorax was associated with a much lower rate of pleurodesis.

Source: Journal of Cardiothoracic & Vascular Anesthesia
Author(s): McNair E, McKay W, Qureshi AM, Rosin M, Gamble J, Dalshaug G, Mycyk T, Prasad K

This article compares 2 methods of residual blood treatment after cardiopulmonary bypass. Multipass hemoconcentration led to higher concentrations of platelets and fibrinogen when compared with centrifugation. Clinical outcomes - weight gain, use of vaso-active agents - were reduced in the hemoconcentration group. Further investigation into methods of treatment of residual blood is warranted.

Source: Annals of Surgery
Author(s): Mattar, Samer G; Alseidi, Adnan A; Jones, Daniel B; Jeyarajah, D. Rohan; Swanstrom, Lee L; Aye, Ralph W; Wexner, Steven D; Martinez, José M; Ross, Sharona B; Awad, Michael M; Franklin, Morris E; Arregui, Maurice E; Schirmer, Bruce D; Minter, Rebecca M

This study examines whether graduating general surgery residents are adequately prepared for fellowship with implications for work hour restrictions.

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): H Nishikawa, T Oto, S Otani, M Harada, N Iga, K Miyoshi, S Miyoshi.

This experimental study in swine investigated the feasibility of using the right and left upper lobes to perform a left unilateral lung transplant.  They found the technique is feasible and may permit use of bilateral upper lobes in donors whose lungs were rejected because of isolated lower lobe issues.

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): NC Cavarocchi, HT Pitcher, Q Yang, P Karbowski, J Miessau, HM Hastings, H Hirose

The authors studied outcomes of using a standard algorithm for weaning venoarterial ECMO using continuous transesophageal echo that employed a miniature probe.  6 of 21 pts had RV and LV recovery, 7 had nonrecoverable LV and RV function, and 8 had RV recovery without LV recovery and underwent LVAD.  RV function was maintained in the latter 8 pts.  The positive predictive value for ventricular recovery was 100% using echo monitoring. 

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): Q Chang, C Tian, Y Wei, X Qian, X Sun, C Yu

Outcomes of 21 pts undergoing hybrid total arch repair without deep hypothermic circulatory arrest for Type A dissection were reviewed.  1 and 12 month survival rates were 95% and 90%.  There was no evidence for caudal migration of the endograft, and only one patient experienced a type I endoleak that was corrected surgically.  No late rupture or paraplegia occurred. 

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): PP Drury, AJ Gunn, L Bennet, A Ganeshalingham, K Finucane, D Buckley, J Beca

This study compared short periods of deep hypothermic arrest to bypass alone in 18 infants undergoing arterial switch to assess neurophysiologic outcomes and white matter injury.  Deep hypothermic arrest was associated with reduced oxygen extraction and transient EEG suppression but there was no difference between the groups in white matter injury.