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Journal and News Scan

Source: Lancet
Author(s): H Thiele, U Zeymer, F-J Neumann, M Ferenc, H-G Olbrich, J Hausleiter, A de Waha, G Richardt, M Hennersdorf, K Empen, G Fuernau, S Desch, I Eitel, R Hambrecht, B Lauer, M Bohm, H Ebelt, S Schneider, K Werdan, G Schuler

Pts with acute MI complicated by shock who were being treated with optimal medical therapy and for whom early revascularization was planned were assigned to IABP vs control.  600 patients were randomized.  Death rates at 12 mos in the IABP and control groups were 52% vs 51%.  Reinfarction, recurrent revascularization, stroke, and quality of life did not differ between the groups. 

Source: Lancet
Author(s): C Bullen, C Howe, M Laugesen, H McRobbie, V Parag, J Williman, N Walker

This 2 year trial randomizing pts between e-cigarettes, placebo e-cigarettes, and nicotine patches was conducted in 657 people.  Abstinence from smoking was achieved in 7.3% for e-cigarettes, 5.8% for patches, and 4.1% for placebo.  Abstinence rates were strikingly low, and aids to smoking cessation offered no important advantage in this small study. 

Source: JAMA
Author(s): F Kim, G Nichol, C MAynard, A Hallstrom, PJ Kudenchuk, T Rea, MK Copass, D Carlbom, S Deem, WR Longstreth Jr, M Olsufka, LA Cobb.

This trial of hypothermia for unconsious survivors of out-of-hospital cardiac arrest randomized 1359 patients to prehospital cooling and hospital cooling.  Prehospital cooling achieved a 1.2º - 1.3º C. decrease in core temperature by the time of arrival to the hospital and reduced time to adequate cooling by 1 hour, but was associated with an increased risk of rearrest prior to hospital arrival.  Survival to hospital discharge (62.7% vs 64.3%) and neurologic status at the time of discharge were similar between the 2 groups.   

Source: New England Journal of Medicine
Author(s): N Nielsen and others for the TTM Trial Investigators

Hypothermia is recommended for unconscious survivors of out-of-hospital cardiac arrest to preserve heart and neurologic function.  This study randomized 950 pts to determine whether 33º C or 36º C is the most appropriate target temperature.  Mortality was similar (50% vs 48%) and outcomes at 180 days for mortality and poor neurologic function were also similar (54% vs 52%). 

Source: Surgery
Author(s): Michael B. Ujiki, Amy K. Yetasook, Matthew Zapf, John G. Linn, Joann M. Carbray, Woody Denham

This study presents a comparison between PerOral Endoscopic Myotomy (POEM) and Standard Laparoscopic Approach in the treatment of achalasia. The authors report satisfactory results of the postoperative course and for grade of patients satisfaction with POEM. The complication incidence was similar for both procedures.

Source: Journal of Heart and Lung Transplantation
Author(s): Wiebke Sommer, Christian Kühn, Igor Tudorache, Murat Avsar, Jens Gottlieb, Dietmar Boethig, Axel Haverich, Gregor Warnecke

The scarcity of lung donors is a worldwide concern. This paper reports a single center experience on use of lungs of marginal donors with a rescue offer system. The results are satisfactory in terms of patients outcome and lung allocation.

Source: Annals of Thoracic Surgery
Author(s): Jennifer Nelson

Jennifer Nelson, the former STS Resident Director, discusses the past, present, and future of cardiothoracic surgery training.  Changes that have occurred in the recent past include removal of the requirement for general surgery certification, the establishment of specialty tracks, and the development of integrated programs.  This has resulted in a large number of applicants for integrated programs and a recent increase in applicants for traditional programs.  The future of our field is bright.

Source: European Journal of Cardiothoracic Surgery
Author(s): Suk-Won Song, Kyung-Jong Yoo, Yoo Rim Shin, Sun-Hee Lim, and Bum-Koo Cho

The authors reviewed their experience between May 2008 and May 2011 with 107 patients who underwent surgical repair for acute Type I aortic dissection. They report favorable results of more effective end-organ protection with the use of intermittent lower body perfusion and moderate hypothermic circulatory arrest.

Source: Radcliffe Cardiology
Author(s): Professor Martin Möckel

Acute myocardial infarction (AMI) may safely be ruled out by testing a single blood sample at patient presentation. In a recently-completed intervention study, using a Copeptin-based diagnostic algorithm enabled immediate discharge of 2/3 of patients with suspected acute coronary syndrome (ACS) from the emergency department. At 30 days, patients managed using Copeptin had 100% survival and a comparably low major cardiovascular event rate (MACE) to that in patients undergoing conventional multiple laboratory testing and hours-long observation. Based on these results, the Thermo Scientific™ B•R•A•H•M•S™ Copeptin biomarker assays improve patient care and clinical resource allocation - without compromising safety.

Source: The New England Journal of Medicine
Author(s): Jean-Louis Vincent and Daniel De Backer

This is a review article of the diagnosis and treatment of the various forms of shock. The treatment of septic shock is well expounded as this makes up 62% of cases of shock in the ICU. Norepinephrine is the first choice of vasopressor agents and dopamine is discouraged due to its arrhythmogenicity. Dobutamine is the first choice of inotropic agents for increasing CO. Low dose of vasopressin in distributive shock is safe and has a survival benefit. Adequacy of circulation is measured by mixed venous saturation with a target of at least 70%. A decrease in blood lactate level signifies effective therapy. The conclusion discusses the four phases of treatment of shock: salvage, optimization, stabilization and deescalation.