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Journal and News Scan

Source: Biomaterials Science
Author(s): Joanna Stasiak, Marta Serrani, Eugenia Biral, James Taylor, Azfar Zaman, Samantha Jones, Thomas Ness, Francesco de Gaetano, Maria Laura Costantino, Vito Domenico Bruno, M.-Saadeh Suleiman, Raimomdo Ascione, Geoff Moggridge

Researchers from the UK reported a novel polymeric heart valve, PoliValve, which is made entirely from styrenic block copolymers. 

The unique feature of PoliValve is that it is made of a self-assembling polymer with a microstructure conferring mechanical anisotropy analogous to that of natural valve tissue. Its prototype substantially exceeds ISO standards for in-vitro testing and shows encouraging preliminary results in acute in-vivo feasibility/safety testing in sheep without anticoagulation. Postmortem confirmed intact structure of the PHV with no evidence of any acute valvular clot/thrombus. Its durability exceeded 1.2 billion cycles in accelerated in-vitro tests, equivalent to 30 patient years. 

These results show that PoliValve is a promising alternative to traditional biological and mechanical valve prostheses, which lasts up to 30 years and does not need anticoagulation. 

Source: Journal of Clinical Oncology
Author(s): Sheraz R. Markar, Melody Ni, Suzanne S. Gisbertz, Leonie van der Werf, Jennifer Straatman, Donald van der Peet, Miguel A. Cuesta, George B. Hanna, and Mark I. van Berge Henegouwen, on behalf of the Dutch Upper GI Cancer Audit and TIME Study Group

The previous randomized study of minimally invasive esophagectomy vs open esophagectomy (TIME trial) conducted in the Netherlands demonstrated reduced pulmonary complications and LOS with MIE.  Compared to the benefits of MIE in those selected high volume centers, national use of MIE was associated with increased overall complications, increased pulmonary complications, and increased reoperation rates. 

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Marcus Mueller, Christoph Hoermandinger, Gregor Richter, Johanna Mulzer, Dmytro Tsyganenko, Thomas Krabatsch, Christoph Starck, Julia Stein, Felix Schoenrath, Volkmar Falk, Evgenij Potapov

This original article retrospectively analyzed the outcome of 200 patients after implantation of HeartMate 3 and HeartWare LVAD respectively. The baseline characteristics of both groups, containing 100 patients each, were comparable, despite a higher percentage of INTERMACS I and II patients implanted with the HeartWare device. While the overall survival was not different, patients receiving HeartWare LVAD had more intracranial bleeding, while the total fraction of patients with cerebrovascular accidents was not different. The authors conclude that the devices show a different complication profile, but comparable intermediate survival.

Source: The Annals of Cardiothoracic Surgery
Author(s): Konstantinos Tsagakis, Davide Pacini, Martin Grabenwöger, Michael A. Borger, Nora Goebel, Wolfgang Hemmer, Alvaro Laranjeira Santos, Thanos Sioris, Kazimierz Widenka, Petar Risteski, Jorge Mascaro, Igor Rudez, Andreas Zierer, Carlos A. Mestres, Arjang Ruhparwar, Roberto Di Bartolomeo, Heinz Jakob

Over the years, frozen elephant trunk (FET) has become the treatment of choice for multisegmental thoracic aortic disease. This multicenter study presents the evolution of FET results using the E-vita Open hybrid graft with respect to institutional experience and time.The data of International E-vita Open registry were studied according to the institutional experience of the participating centers (high- versus low-volume centers) and according to the evolution of FET treatment during time (1st period, 2005–2011 versus 2nd period, 2012–2018). Overall, 1,165 patients were enrolled in the study with a wide variety of multisegmental thoracic aortic pathologies and aortic emergencies. Participating centers determined their own surgical protocol.The overall 30-day mortality was 12%. Short- and long-term survival were higher in high- versus low-volume centers (P=0.048 and P=0.013, respectively). In the 2nd time period, cerebral complications were reduced significantly (P=0.015). Incidence of permanent spinal cord-related symptoms was reduced to 3% in the 2nd time period, but did not reach statistical significance. Hypothermic circulatory arrest time (P<0.001) and incidence of postoperative temporary renal replacement therapy (P=0.008) were significantly reduced in the 2nd time period. Ten-year survival and freedom from aortic-related death rates were 46.6% and 85.7%, respectively, for the entire group. The freedom from distal aortic re-interventions for a new or progressive residual aortic disease was 76.0%. In conclusion, this study shows that the evolution of FET arch repair techniques with the E-vita Open graft and increasing institutional experience were associated with improved results. Progression of residual aortic disease makes close follow-up with aortic imaging mandatory in such patients.

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): Joseph S. Coselli, Susan Y. Green, Matt D. Price, Qianzi Zhang, Ourania Preventza, Kim I. de la Cruz, Richard Whitlock, Hiruni S. Amarasekara, Sandra J. Woodside, Andre Perez-Orozco, Scott A. LeMaire,

A large retrospective review of almost three decades of extensive thoracoabdominal aortic surgery, with considerable educational value especially on the anatomicoclinical correlations of the spinal vasculature.

Source: The Annals of Thoracic Surgery
Author(s): Zehang Chen, Chase Brown, Fabliha Khurshan, Maximillian Kreibich, Fenton McCarthy, Joseph E. Bavaria, Nimesh D. Desai

The authors analyzed the volumes of thoracic endovascular aneurysm repair (TEVAR) for the treatment of descending thoracic aneurysms for Medicare patients over five years, comparing the proportion of cases to 30-day mortality.

Source: Journal of the American College of Cardiology: Cardiovascular Interventions
Author(s): Oliver K. Jawitz, Brian C. Gulack, Maria V. Grau-Sepulveda, Roland A. Matsouaka, Michael J. Mack, David R. Holmes Jr., John D. Carroll, Vinod H. Thourani and J. Matthew Brennan

As TAVR is used in progressively lower-risk cohorts, management of device failure will become increasingly important. This study reports the largest series of patients receiving a surgical reoperation after transcatheter aortic valve replacement (TAVR) using the STS Adult Cardiac Surgery Database. A total of 123 patients met inclusion criteria, and cases represent predominantly early TAVR failure (months to a few years from index procedure). Reoperation was associated with an operative mortality of 17.1% and other worse-than-expected outcomes when compared with similar patients initially undergoing surgical aortic valve replacement. Continued experience with this developing technology is needed to reduce the incidence of early TAVR failure and further define optimal treatment of failed TAVR prostheses.

Source: World Journal for Pediatric Congenital Heart Surgery
Author(s): Emily Levy, Jennifer Blumenthal, Kathleen Chiotos, and Joseph A. Dearani

This review provides a concise summary of frequently asked questions related to COVID-19 in children with congenital heart disease. 

Source: The Annals of Thoracic Surgery
Author(s): Tejas S. Sathe, Benjamin J. Resio, Jessica R. Hoag, Andres F. Monsalve, Ranjan Pathak, Justin D. Blasberg, Vincent Mase Jr., Andrew Dhanasopon, Daniel J. Boffa

The authors compared surgically managed signet ring cell adenocarcinoma and esophageal adenocarcinoma patients in the National Cancer Database.

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Sho Kusadokoro, Naoyuki Kimura, Daijiro Hori, Masahiro Hattori, Wataru Matsunaga, Ryo Itagaki, Koichi Yuri, Makiko Mieno, Masanori Nakamura, Atsushi Yamaguchi

This manuscript by Kusadokoro et al. retrospectively looks into the outcome of patients who underwent either planned or rescue double arterial cannulation in surgery for type A aortic dissection. The propensity match analysis proofed non-inferiority of double arterial cannulation regarding one- and five-year survival. The authors conclude double arterial cannulation to be safe for management and prevention of malperfusion during surgery for type A aortic dissection.