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Journal and News Scan
Chronic lung allograft dysfunction (CLAD) is associated with significant morbidity after lung transplantation, however, at the time of diagnosis of CLAD, the disease process has usually adversely impacted graft function. The authors studied a scoring system based on the Airway Inflammation 2 (AI2) gene set and found that this score predicted time to graft failure as well as retransplant free survival in patients with CLAD, as compared to a validation cohort that included non-CLAD patients. Although there may be a component of survival bias during matching, this is a highly interesting area of research that could have important clinical implications in early identification of CLAD.
This consensus statement disseminated by the International Society for Heart and Lung Transplantation (ISHLT) focuses on the prevention and management of hemocompatability-related adverse events (HRAEs) in patients with durable, continuous-flow left ventricular assist devices (CF-LVAD). As survival in this group of patients continues to improve with advances in technology, HRAEs remain a concern. The ISHLT summarizes the literature in this field and shares several recommendations including management of antiplatelet agents, oral anticoagulation, management of high-risk patients, and management of bleeding or clotting events based on different existing devices.
Congenital and pediatric cardiac surgery are among the most complex, high-stake medical specialties, which requires exceptional cognitive and technical skills. Despite advances in technology and patient safety, the training for future surgeons in this field faces significant challenges. Issues include the increasing complexity of surgeries, reduced opportunities for simpler cases, strict work hour regulations, and public scrutiny of outcomes. These factors contribute to a crisis in training, with many trainees and young surgeons expressing dissatisfaction.
Mentorship is crucial in overcoming these challenges. It involves a stepwise approach to teaching surgical skills, ongoing guidance during early years of practice, and leadership training for managing interdisciplinary teams. Effective mentorship not only improves technical proficiency but also enhances emotional intelligence and resilience. Despite the lack of tangible rewards and the significant time commitment required, mentoring enriches both the mentor and mentee, ultimately benefiting patient care and advancing the field.
Penetrating thoracic injuries have high risks of morbidity and mortality, with severe pulmonary vascular and bronchial injuries sometimes necessitating post-traumatic pneumonectomy and perioperative ECMO support due to right ventricular and respiratory failure. This case describes a male with a penetrating thoracic injury presenting with a massive right hemothorax and active bleeding, requiring ligation of the right pulmonary hilum. He subsequently developed right ventricular dysfunction and ARDS, necessitating a dynamic hybrid ECMO configuration to support his recovery. This case highlights that ECMO support can reduce mortality and complications in such severe injuries. Effective management requires a multidisciplinary team for optimal outcomes in severely compromised patients.
Ischemic cardiomyopathy (ICM) causes more than 60 percent of congestive heart failure cases, leading to high morbidity and mortality. Myocardial revascularization is vital for patients with left ventricular dysfunction (LVD) and an ejection fraction (LVEF) ≤ 35 percent, aiming to improve survival rates and quality of life. Despite its importance, randomized clinical trials often exclude these patients, relying on observational data. A recent review evaluated surgical revascularization strategies, highlighting ONCABG for multivessel disease in LVD patients with LVEF < 35 percent, and OPCAB for older, high-risk patients. Techniques such as internal thoracic artery skeletonization, BITA, and postoperative glycemic control are crucial for managing risks. Total arterial revascularization improves long-term survival, while hybrid revascularization reduces hospital stays and costs. This review emphasizes the need for tailored revascularization strategies in severe LVD patients.
Recent percutaneous revascularization of unprotected left main disease has generated a debate about the outcomes after percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) disease. The authors in this metanalysis used four randomized control trials and 10 adjusted observational studies, which total 24,767 patients to compare PCI with CABG. Within the limitations of a meta-analysis, which includes the limitations and inherent biases of all the individual studies involved, PCI was found to be associated with a higher risk of all-cause death and repeat revascularization compared to CABG. In the elderly population, PCI and CABG appeared to have similar outcomes, but there was a higher risk of major adverse cardiac events (MACE) with PCI.
As the understanding of the natural progression of smaller peripheral lung nodules grows, the treatment options and existing paradigms continue to change. One area that is under intense study involves ground glass nodules (GGOs), which are detected by high resolution CT scans. The authors summarize the recent efforts to classify the aggressiveness of GGOs on imaging with the resulting pathology noted after surgical resection and discuss how such lesions can be over and under treated based on existing classification systems. The authors also discuss algorithms to aid in individualized patient selection for sublobar resections with such lesions.
While treatment of classic septal hypertrophic cardiomyopathy is well established, the treatment for long segment subaortic variant and apical hypertrophy variants are less clearly defined. The apical variant has traditionally been treated with a heart transplant, however, there is emerging experience with a transapical approach to treat this condition that may be used as an alternate to a heart transplant. The researchers reference a twenty-two-year-old patient who was successfully treated with this approach and suggest it may be used for other ventricular septal defect closures and endocardial fibroelastosis.
Determining the appropriate prosthetic for mitral valve replacement is an ongoing area of study. This article looked at trends at a single center over a period of 20 years and compared the use of biologic (1,658 patients) and mechanical valves (369 patients). Survival among groups was similar, however, patients with mechanical valves had significantly lower incidence for reoperation overall. The researchers discuss the established durability of mechanical valves, pitfalls of selection bias in patients of different age groups and across eras, and they share comparisons with existing data in the literature from other centers of excellence.
Treatment of aortic stenosis due to a bicuspid aortic valve (BAV), requires a lifetime strategy due to structural valve degeneration that necessitates redo intervention, such as surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). The researchers looked at outcomes for surgical valve replacement in patients with and without concomitant aortic aneurysms, and have reported excellent operative and reoperative outcomes, including durability at 10 years and valve function. The researchers make a case for performing surgical valve replacement versus TAVR in younger patients for several reasons, including the favorable operative and reoperative safety profile, ability to intervene on concomitant pathology (such as aneurysmal disease and atrial fibrillation), and established long-term durability profile.