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Efficacy of a Device to Narrow the Coronary Sinus in Refractory Angina

Wednesday, February 4, 2015

Submitted by

Mark Ferguson

Source

Source Name: New England Journal of Medicine

Source URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1402556?query=TOC

Author(s)

Stefan Verheye, E. Marc Jolicœur, Miles W. Behan, Thomas Pettersson, Paul Sainsbury, Jonathan Hill, Mathias Vrolix, Pierfrancesco Agostoni, Thomas Engstrom, Marino Labinaz, Ranil de Silva, Marc Schwartz, Nathalie Meyten, Neal G. Uren, Serge Doucet, Jean-François Tanguay, Steven Lindsay, Timothy D. Henry, Christopher J. White, Elazer R. Edelman, and Shmuel Banai

104 patients with class III or IV angina who were not candidates for revascularization were randomized to a sham procedure or to placement of a coronary sinus narrowing device. 35% of those in the device group improved their angina 2 classes, and 71% improved by 1 class, compared to 15% and 42% in the sham group. Quality of life improved more in the treatment group. Improvement in exercise capacity and in ventricular wall motion were similar between the groups.