A severe blow to the concept of venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome in the form of a well-executed randomized controlled trial.
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Lung - Basic Science
Discussion of "Intraoperative Extracorporeal Membrane Oxygenation and the Possibility of Postoperative Prolongation Improve Survival in Bilateral Lung Transplantation"
May 3, 2018
A stimulating discussion of the Vienna paper that advances elective ECMO support for bilateral pulmonary transplantation.
In Global News: Boy Band-Induced Collapsed Lung, Magnet Esophageal Anastomosis, and AKI After Heart Surgery
October 13, 2017
February 20, 2016
A succinct editorial from a British academic transplant surgeon. It discusses the need for stratifying the utilization of donor lungs based on recent and previous retrospective papers from North American and European databases. Professor Dark also briefly debates the needs for research on assessing and optimizing the organs.
Integrating Tumor and Stromal Gene Expression Signatures With Clinical Indices for Survival Stratification of Early-Stage Non–Small Cell Lung Cancer
August 26, 2015
Investigators from Stanford developed a nine-gene expression predictor for survival outcome in early-stage nonsquamous NSCLC. They developed and validated a quantitative real-time polymerase chain reaction assay easily applicable to routinely obtained paraffin-embedded tumor specimens.
March 21, 2015
Concerns remain about the definition of a high risk population who can benefit from low-dose computed tomography screening programs.
March 12, 2015
Samples from tissue microarrays of 552 NSCLC patients were analyzed to measure the levels of 3 different tumor-infiltrating lymphocytes (TILs): CD3, CD8, and CD20. An elevated level of CD3 or CD8 was associated with longer survival.
March 1, 2015
The increasing prevalence of multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB) in some countries is alarming. When few therapeutic options remain, old procedures need to be re-evaluated based on evidence, specially, surgery.
Aerogenous Metastases: A Potential Game Changer in the Diagnosis and Management of Primary Lung Adenocarcinoma
December 10, 2014
This interesting article summarizes the evidence from clinical, radiologic and pathologic investigations that lung cancer, specifically adenocarcinoma, may metastasize through the airways, defined as discontinuous spread of cancer cells from the primary tumor through the airways to adjacent or distant lung parenchyma.
December 2, 2014
This is an interesting historical vignette describing the discovery of transfer factor (TLCO, DLCO) and its subsequent importance in pulmonary physiology and cardiorthoracic risk assessment.