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miR-Test: A Blood Test for Lung Cancer Early Detection

Saturday, March 21, 2015

Submitted by

Marcelo Jimenez

Source

Source Name: Journal of the National Cancer Institute

Source URL: http://jnci.oxfordjournals.org/content/107/6/djv063.abstract?ct

Author(s)

Francesca Montani, Matteo Jacopo Marzi, Fabio Dezi, Elisa Dama, Rose Mary Carletti, Giuseppina Bonizzi, Raffaella Bertolotti, Massimo Bellomi, Cristiano Rampinelli, Patrick Maisonneuve, Lorenzo Spaggiari, Giulia Veronesi, Francesco Nicassio, Pier Paolo Di Fiore and Fabrizio Bianchi

Concerns remain about the definition of a high risk population who can benefit from low-dose computed tomography screening programs. In this paper, the authors present a promising tool to optimize lung cancer screening in a high-risk population using a serum microRNA signature (miR-Test). The area under the ROC curve of test is 0.85 (95% CI = 0.78 to 0.92).