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Previous Lung Volume Reduction Surgery Does Not Negatively Affect Survival After Lung Transplantation

Friday, March 9, 2018

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Source Name: European Journal of Cardio-Thoracic Surgery


Ilhan Inci, Ilker Iskender, Jonas Ehrsam, Claudio Caviezel, Sven Hillinger, Isabelle Opitz, Didier Schneiter, Walter Weder

Inci and colleagues reviewed prospectively collected data from 117 patients with end-stage emphysema undergoing lung transplantation. The authors found that short-term and long-term survival were equivalent in patients who did and did not undergo lung volume reduction surgery prior to their transplantation (107 versus 86 months, p = 0.6).


I feel that the primary research question would be : optimal intervention in end stage empysema thoracis, how emphysema sufferers fare with no surgery vs. LVRS only, uni - or bilateral sequential pulmonary transplantation only, and lastly LVRS followed by Tx with the mortality of LVRS dealt as an intention to treat, unless explicitly known that LVRS was as bridge. We need a multi arm RCT or at least apply the question to the Zurich cohort. The main limitation is the heterogeneity of emphysema. main limitation is the heterogenicity of emphysema.

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