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Effect of Remote Ischemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery

Friday, May 29, 2015

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Alexander Zarbock; Christoph Schmidt; Hugo Van Aken; Carola Wempe; Sven Martens; Peter K. Zahn; Britta Wolf; Ulrich Goebel; Christian I. Schwer; Peter Rosenberger; Helene Haeberle; Dennis Görlich; John A. Kellum; Melanie Meersch; for the RenalRIPC Investigators

240 high risk patients undergoing cardiac surgery were randomized to remote ischemic preconditioning (3 5-min cycles of single upper extremity ischemia after anesthetic induction) or sham.  Preconditioning reduced the incidence of acute kidney injury by one-third and the need for renal replacement therapy by two-thirds.  These results were associated with changes in urinary insulinlike growth factor–binding protein 7 and tissue inhibitor of metalloproteinases 2.  No differences were found between the groups for other major complications.

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