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Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial

Saturday, September 26, 2015

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Richard P Whitlock, PJ Devereaux, Kevin H Teoh, Andre Lamy, Jessica Vincent, Janice Pogue, Domenico Paparella, Daniel I Sessler, Ganesan Karthikeyan, Juan Carlos Villar, Yunxia Zuo, Álvaro Avezum, Mackenzie Quantz, Georgios I Tagarakis, Pallav J Shah, Seyed Hesameddin Abbasi, Hong Zheng, Shirley Pettit, Susan Chrolavicius, and Salim Yusuf for the SIRS Investigators

In this RCT, patients at increased risk for cardiac surgery requiring CPB were assigned to steroids at the time of anesthetic induction and again at the time of CPB induction or no steroids.  Primary outcomes were 30-day mortality and major morbidity.  Steriods had no effect on the primary outcomes.  There was no evidence that steroids increased the risk of other complications, particularly infection, surgical site infection, and delirium.

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