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Esophagus - Cancer

December 24, 2015
Whether postoperative adjuvant therapy for node-positive residual disease after induction therapy and resection for esophageal cancer is unknown.  This single institution study identified 101 node positive patients among 764 treated with induction therapy and surgery during 2000-2012.  45 of 101 patients who underwent adjuvant therapy, primarily chem
December 23, 2015
This longitudinal review of single institution experience with GEJ adenocarcinomas identified time-related trends.  The proportion of GEJ tumors compared to all esophageal cancers increased from 22% to 36%.  GERD increased from 7% to 11%.  An increased in GERD was associated with an increased in the prevalance of Seiwert I tumors.  There was  a signi
November 15, 2015
The goal of this study was to detemine whether adjuvant chemotherapy leads to a survival benefit in patients with positive LNs who have undergone induction chemoradiation therapy followed by esophagectomy. This is a retrospective study of 764 patients undergoing esophagectomy at a single institution from 2000-2013.
November 11, 2015
A French multicenter database was used to assess the relationship between severe anastomotic leak on outcomes after esophagectomy.  Among 2439 pts, 8.5% developed a severe leak.  This was associated with lower median overall survival (36 mos vs 55 mos) and disease-free survival (34 mos vs 48 mos), a 28% increased likelihood of death, and a significan
October 12, 2015
This single institution study evaluated compliance with NCCN guidelines in the management of stage II-III esophageal cancer.  Overall compliance was 81%, and was related to younger age, white race, and higher education level.  Compliance was associated with improved survival.
September 16, 2015
The 6th and 7th versions of the AJCC staging system were compared for their prognostic accuracy for patients with esophagogastric adenocarcinomas using an institutional database.  The 7th edition system was significantly more accurate in groups undergoing MIE, induction therapy, and overall.
September 8, 2015
This single institution study involving 606 patients operated 2000-2012 examined the influence of the extent of lymphadenectomy on survival.  The number of nodes resected was not related to all-cause mortality, even comparing the highest and lowest quartiles.  The number of metastatic nodes and an increasing ratio of positive to negative nodes were e
July 23, 2015
This multicenter retrospective study evaluated the efficacy of salvage esophagectomy after definitive chemoradiotherapy compared to planned esophagectomy after induction chemoradiotherapy.  Operative mortality was similarly high in both groups (8.4% vs 9.3%).  Anastomotic leak was higher after salvage esophagectomy (17.2% vs 10.7%).  3-year survival
July 17, 2015
Retrospective study of 917 patients undergoing esophagectomy for squamous cell carcinoma at a single hospital in China. In the 7th version of the AJCC staging system for esophageal cancer, nodal stage (N stage) is based solely on the number of lymph node (LN) metastases.
July 14, 2015
This important consensus statement on definitions of postoperative complications after esophagectomy was developed by an international group of surgical experts.  It should serve as a template for data collection and reporting for clinical reports and trials.

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