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Cytisine versus Nicotine for Smoking Cessation

Thursday, December 18, 2014

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Source Name: New England Journal of Medicine


Natalie Walker, Colin Howe, Marewa Glover, Hayden McRobbie, Joanne Barnes, Vili Nosa, Varsha Parag, Bruce Bassett, and Christopher Bullen

This randomized trial in New Zealand assigned smokers who wished to quit to either nicotrine replacement therapy or cytisine therapy. At 1 mon more patients reported continuous abstinence from cigarettes in the cytisine group than in the nicotine replacement group (40% vs 31%).  Cytisine was more effective at 1 week, 2 mos, and 6 mos.  Cytisine was superior to nicotine replacement in women and was non-inferior in men.  Self-reported adverse events were more common in the cytisine group.

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