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Cytisine versus Nicotine for Smoking Cessation
This randomized trial in New Zealand assigned smokers who wished to quit to either nicotrine replacement therapy or cytisine therapy. At 1 mon more patients reported continuous abstinence from cigarettes in the cytisine group than in the nicotine replacement group (40% vs 31%). Cytisine was more effective at 1 week, 2 mos, and 6 mos. Cytisine was superior to nicotine replacement in women and was non-inferior in men. Self-reported adverse events were more common in the cytisine group.