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Lung Cancer - Other

May 30, 2018
The addition of pembrolizumab (targeting PD-1) to standard chemotherapy substantially improved time to progression and overall survival compared to chemotherapy alone in patients with metastatic lung cancer.
May 23, 2018
The age-specific incidence of non-small cell lung cancer has reversed in individuals born since the 1960s, with women now having a higher incidence than men.  This trend is not explained by differences in smoking habits.
May 23, 2018
This is among the first and largest summaries of the use of neoadjuvant PD-1 inhibitor (nivolumab) in patients with resectable lung cancer.  The safety profile was adequate, 20 of 21 patients underwent complete resection, and the pathologic major response rate was 45%.   The response was similar regardless of PD-L1 status, and response was related to
May 23, 2018
Using eight computed tomography radiographic features in an automated algorithm, differentiating between benign and malignant status of indeterminate pulmonary nodules had an area under the curve of 0.939. 
March 23, 2018
Patient Care A teen in Chicago, Illinois, USA, awaiting a heart transplant received the news that a heart was available from his pediatric cardiologist, who dressed up as Chewbacca from Star Wars just for the occasion.
March 23, 2018
Surgery for cancer is known to suppress immune response and facilitate the development of metastases.  In this study in mice, a scaffold designed to release agonists of innate immunity over time was placed in the bed of resected tumors.  The treatment reduced local recurrence and improved survival. 
February 23, 2018
A comprehensive review of pleural diseases from the internists' viewpoint. Relevant to surgeons in the sense of referrals for empyema, pleural effusions, and other traditional surgical problems that are now often dealt with revitalised internist-led options such as office pleuroscopy/pleurodesis.
January 22, 2018
A model analysis of a phase I surgical device trial. The readable editorial discusses the adoption of surgical innovation on the occasion of a harmonic sealing device for pulmonary resections, highlighting the problem of ligating small branches of the pulmonary artery in confined spaces. 
December 13, 2017
Liquid biopsies have long held promise for diagnosis, treatment selection, and surveillance of lung cancer patients.  This articles summarizes results of two studies involving highly precise measurement of tumor mutational burden.  A burden of 16-fold or greater was associated with improved overall survival with immunotherapy (atezolizumab) compared

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