Stephen Hazelrigg, Neil Christie, and Hiran Fernando discuss the use of stereotactic body radiation therapy (SBRT) in the treatment of lung cancer.
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Lung Cancer - Other
July 9, 2015
June 24, 2015
The ELCAP data set was evaluated for pts identified with non-solid nodules at baseline or during follow-up. 2392 (4.2%) pts had nonsolid nodules at baseline, of which 73 were diagnosed as adenocarcinoma. A new nodule was identified in an additional 485 (0.7%) pts, of whom 11 were diagnosed with adenocarcinoma. Nonsolid nodules improved in 66% of
FDG Uptake on Positron Emission Tomography Correlates with Survival and Time to Recurrence in Patients with Stage I Non–Small-Cell Lung Cancer
May 22, 2015
In this retrospective review of 336 patients treated surgically for early stage NSCLC, the prognostic value of PET SUV was evaluated. Risks of recurrence and death increased steadily as SUV increased.
May 19, 2015
Pts with suspected lung cancer underwent sampling of normal-appearingbronchial epithelial cells in the main bronchi, unrelated to the suspected tumor. Gene expression was analyzed and classified. Classification for cancer was about 75% accurate.
Tumor Spread through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas
April 23, 2015
The authors reviewed patients with small resected stage I lung adenocarcinoma to determine the frequency of tumor cells spreading through airway spaces (STAS) and their relationship to recurrent cancer. Nearly 40% of patients had tumor cells in the airways beyond the edge of the main tumor. In patients undergoing parenchymal-sparing operations, the
Variation in causes of death in patients with non-small cell lung cancer according to stage and time since diagnosis
March 16, 2015
This Netherlands population-based study followed causes of death in patients with NSCLC diagnosed 1989-2008, including more than 72,000 patients. For those with localized disease, lung cancer was the cause of death in 80-85% for years 0-3, 60-75% for years 4-6, and remained the cause of death for more than 30% thereafter. After 6 years CAD and COPD
March 16, 2015
The authors describe results of initial bronchoscopy therapy (IBT) for endobronchial carcinoids aimed at relieving obstruction, accurate subtyping, and potentially complete eradication. After a minimum follow-up of 5 years, 42% of patients were spared surgical therapy, having had no evidence of local or distant recurrence (42/83 with typical histolo
February 21, 2015
A survey involving the general public identified opinions regarding lung cancer. Most felt it was related to smoking and lifestyle, was a serious cancer, and involved major treatments. The participants underestimated cure rates for early stage disease (52% survival) and overestimated overall survival (32% survival).
Effect of Prior Cancer on Outcomes in Advanced Lung Cancer: Implications for Clinical Trial Eligibility and Accrual
February 16, 2015
Usually patients with prior cancer are excluded in lung cancer trials, but the impact on survival in lung cancer is not known. In a cohort of 102929 patients older than 65 with stage IV lung cancer, a propensity score analysis were performed and found that patients with prior cancer had better survival (all-cause and lung cancer-specific).
February 16, 2015
This trial randomized 61 pts to a program of endurance and strength training or no training beginning 5-7 weeks after lung resection for cancer and lasting 20 weeks. Compared to controls, treatment group patients demonstrated significant improvements in peak O2 uptake, DLCO, leg and arm strength, muscle mass, and QOL.