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Journal and News Scan
This is the largest analysis of COVID-19 related impact on adult cardiac surgery volume, trends, and outcomes. During the pandemic, cardiac surgery volume suffered dramatically, particularly in the Mid-Atlantic and New England regions during the first COVID-19 surge, with a concurrent increase in observed-to-expected 30-day mortality.
Interesting multi-center RCT that paves the way for potential paradigm shifts in antithrombotic modulation. The abcence of symptomatic pulmonary embolism warrants further investigation...
Although the standard of care in the West for regionally advanced esophageal cancer entails induction therapy, this is routinely not the case in China. This randomized trial involving over 450 randomized participants to induction therapy (vinorelbine, cisplatin, 40 Gy RT) followed by resection vs resection alone. At a median f/u of 53.5 mos, trimodality therapy demonstrated overall (HR 0.74; CI 0.57-0.97) and disease free (HR 0.60; CI 0.45 to 0.80) survival advantages compared to surgery alone. This study may establish a new standard of care for management of resectable regionally advanced esophageal cancer in China.