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Journal and News Scan

Source: News from around the web.
Author(s): Claire Vernon

Patient Care and General Interest

As state-specific regulations around marijuana change in the US, physicians and surgeons express concern about the dearth of information about the potential long-term harmful effects of smoking the drug.

A teenage heart transplant recipient has partnered with a chef to create a heart-healthy cookbook.

A genetically-engineered bacteriophage infusion is used to treat a lung transplant recipient’s drug-resistant infection in London, UK.

Patients don’t understand their implanted pacing devices as well as they think they do, and they also want to know more about their devices.

Australian professional golfer Jason Day has partnered with AstraZeneca to raise awareness of biomarker testing for lung cancer, following his mother’s diagnosis of late stage cancer.


Drugs and Devices

A medical device alternative summary reporting program from the US Food and Drug Administration (FDA) will be shut down, and past records will be made publicly available.

The US FDA has issued a safety communication, alerting providers that the batteries in certain pacemakers or cardiac resynchronization therapy pacemakers from Medtronic can fail early.


Research, Trials, and Funding

Research presented at the recent Annual Meeting of the American Association for Thoracic Surgery in Toronto, Canada, evaluated the use of an ultrasonic vessel-sealing device in minimally invasive lobectomy.

Healthy novice runners who trained for their first marathon showed a reduction in aortic stiffness, say researchers from University College London.

Researchers from London report in Nature the usage of microRNA to induce cardiac regeneration after heart attack in pigs.

Source: The Journal of Thoracic and Cardiovascular Surgery
Author(s): Andras P. Durko, Stuart J. Head, Philippe Pibarot, Pavan Atluri, Vinayak Bapat, Duke E. Cameron, Filip P.A. Casselman, Edward P. Chen, Gry Dahle, Tjark Ebels, John A. Elefteriades, Patrizio Lancellotti, Richard L. Prager, Raphael Rosenhek, Alan Speir, Marco Stijnen, Giordano Tasca, Ajit Yoganathan, Thomas Walther, Ruggero De Paulis, EACTS–STS–AATS Valve Labelling Task Force

Intraoperative surgical prosthetic heart valve (SHV) choice is a key determinant of successful surgery and positive postoperative outcomes. Currently, many controversies exist around the sizing and labeling of SHVs rendering the comparison of different valves difficult. To explore solutions, an expert Valve Labelling Task Force was jointly initiated by the European Association for Cardio-Thoracic Surgery (EACTS), The Society of Thoracic Surgeons (STS) and the American Association for Thoracic Surgery (AATS). The EACTS–STS–AATS Valve Labelling Task Force, comprising cardiac surgeons, cardiologists, engineers, regulators and representatives from the International Organization for Standardization (ISO), and major valve manufacturers, held its first in-person meeting in February 2018 in Paris, France. This article was derived from the meeting's discussions.

The Task Force identified the following areas for improvement and clarification: reporting of physical dimensions and characteristics of SHVs determining and labeling of SHV size, in vivo and in vitro testing, and reporting of SHV hemodynamic performance and thrombogenicity. Furthermore, a thorough understanding of the regulatory background and the role of the applicable ISO standards, together with close cooperation between all stakeholders (including regulatory and standard-setting bodies), is necessary to improve the current situation. Cardiac surgeons should be provided with appropriate information to allow for optimal SHV choice. This first article from the EACTS–STS–AATS Valve Labelling Task Force summarizes the background of SHV sizing and labeling and identifies the most important elements where further standardization is necessary.

Source: The Annals of Thoracic Surgery
Author(s): Dana Y. Fuhrman, Lan G. Nguyen, Joan Sanchez-de-Toledo, Priyanka Priyanka, John A. Kellum

Fuhrman and colleagues investigated the occurrence of acute kidney injury (AKI) in young adults with congenital heart disease undergoing a surgical procedure, a group of patients that is increasing in number. They retrospectively analyzed data for 699 patients between 18 and 40 years of age who were admitted to a children’s hospital's cardiac intensive care unit over an 11 year time period. AKI occurred in 13.2% of these patients. Suspected sepsis, exposure to calcineurin inhibitors, vancomycin, and piperacillin-tazobactam increased the odds of injury, even after controlling for several factors including repeat cardiopulmonary bypass.

The authors conclude that postoperative AKI is common in young adults with congenital heart disease and is associated with adverse outcomes. They also suggest that care be taken in the use of potentially nephrotoxic medications.

Source: Interactive Cardiovascular and Thoracic Surgery
Author(s): Marcin Ostrowski, Tomasz Marjański, Robert Dziedzic, Małgorzata Jelitto-Górska, Katarzyna Dziadziuszko, Edyta Szurowska, Rafał Dziadziuszko, Witold Rzyman

Ostrowski and colleagues report on the results of two lung cancer computed tomography screening programs that, when combined, included more than 14,000 smokers older than 50 years. The incidence of lung cancer was 1-2%. A total of 4% of patients were referred for further invasive diagnostic follow-up. Surgical resection was necessary in 1.5%. The authors found that modified inclusion criteria in one of the screening programs lead to a different detection rate of non–small cell lung cancer.

Source: News from around the web.
Author(s): Claire Vernon

Patient Care and General Interest

A roadside thoracotomy was performed in the UK to control severe bleeding for a man who was stabbed, and the procedure was captured on video.

The 30-day public comment period for the US national coverage decision for transcatheter aortic valve replacement has closed, and this brief Cardiovascular Business article summarizes the public response.

Public health officials in the UK call for greater awareness of lung cancer in individuals who have never smoked tobacco.

Several health associations have voiced support for the Tobacco to 21 Act, legislation that was introduced in the US Congress that would raise the minimum federal age to purchase tobacco products.


Drugs and Devices

The US Food and Drug Administration (FDA) has categorized a recall of Miller Balloon and Fogartey Dilation Atrioseptostomy Catheters, issued in March by Edwards Lifesciences, as a Class I recall.

An active fixation lead for quadripolar cardiac resynchronization therapy defibrillators and pacemakers, the Attain Stability Quad left heart lead from Medtronic, is approved by the US FDA.


Research, Trials, and Funding

Lung cancer presents differently in patients with idiopathic pulmonary fibrosis, say researchers in New York City, New York, USA.

Researchers in London, UK, report that the addition of an informational video to a brochure on lung cancer screening improved patients’ understanding and reduced conflicted feelings about whether to undergo the screening.

A study in piglets found that adding hydrogen to ventilation gasses during and after arrested blood flow improved neuroprotection, and the researchers from Boston, Massachusetts, USA, are now aiming to translate these results to people.

Source: US Food and Drug Administration
Author(s): US Food and Drug Administration

The US FDA approved the Xvivo device for maintaining or resuscitating donor lungs prior to transplant. Interesting very high survival is reported in the control group at one year.

Source: The Annals of Thoracic Surgery
Author(s): Vinod H. Thourani, Sean M. O'Brien, John J. Kelly, David J. Cohen, Eric D. Peterson, Michael J. Mack, David M. Shahian, Frederick L. Grover, John D. Carroll, J. Matthew Brennan, Jessica Forcillo, Suzanne V. Arnold, Sreekanth Vemulapalli, Susan Fitzgerald, David R. Holmes, Joseph E. Bavaria, Fred H. Edwards

Thourani and colleagues used data from The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry to develop a risk model for in-hospital stroke after transcatheter aortic valve replacement (TAVR), a serious complication. Of the 97,600 TAVR procedures performed between 2014 and 2017 that were included in the analysis, 1,839 patients experienced in-hospital stroke. The authors limited covariate selection to patient demographics and baseline characteristics—with the one exception being access strategy—to increase the usefulness of the model prior to a procedure. Predictors for increased stroke risk included alternative access, prior stroke, procedural acuity, smoking, porcelain aorta, peripheral artery disease, and advanced age.

Additionally, the authors report that patients at 10 of the 521 participating sites were found to have significantly higher odds ratios for stroke than the other sites. They note that the model thus serves as a resource for quality improvement as well as for clinical decision making and patient counseling.

Source: The New England Journal of Medicine
Author(s): Catherine M. Otto

The overarching, free to read under terms, of the TAVR mini-compendium of this week: the most complex question remains "what is a reasonable expectation of a stakeholder on outcomes of aortic stenosis?"

Source: Annals of Cardiothoracic Surgery
Author(s): Carmelina C. Zirafa, Gaetano Romano, Teresa Hung Key, Federico Davini, Franca Melfi

Melfi and colleagues present a keynote lecture outlining the evolution of robotic thoracic surgery. The robotic technique in thoracic surgery has progressively become widespread, particularly for the treatment of mediastinal and pulmonary lesions. The authors discuss the development of technology in the robotic system that has been associated with the improvement of intraoperative and postoperative results.

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Yoshiyuki Yamashita, Yasuhisa Oishi, Yuma Motomatsu, Kazuto Hirayama, Takeaki Harada, Tomoki Ushijima, Satoshi Fujita, Satoshi Kimura, Hiromichi Sonoda, Hideki Tatewaki, Yoshihisa Tanoue, Genya Sunagawa, Takuya Nishikawa, Keita Saku, Akira Shiose

Aortic endografting leads to aortic stiffening. In this experimental animal study, Yamashita and colleagues evaluated the effect that thoracic endografting had on cardiac afterload, function, and remodeling. The authors report increased aortic input impedance and left ventricular mass after three months, although the effect of experimental descending aorta endografting on left ventricular contractility and efficiency was minimal.