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Journal and News Scan
Beckers and colleagues evaluated toxicity and outcomes of regional chemotherapeutic treatment with isolated lung perfusion of melphalan combined with metastasectomy for patients with resectable pulmonary metastases. The prospective study included 107 patients with metastases of colorectal carcinoma, osteosarcoma, or soft-tissue sarcoma. The authors report low morbidity and no long-term pulmonary toxicity. The disease-free and progression-free rates at 5 years were 26% and 44% for patients with colorectal carcinoma and 29% and 63% for patients with sarcoma. The authors conclude that isolated lung perfusion with melphalan combined with metastasectomy is both feasible and safe, and that further evaluation of this approach is warranted.
This narrated video highlights an aortic valve repair performed for a 47-year-old man who presented with severe, symptomatic aortic regurgitation on a quadricuspid valve. The repair was performed through a median sternotomy using conventional cannulation for cardiopulmonary bypass, and Mastrobuoni and colleagues extensively outline their technique for “tricuspidization.” Additionally, the authors discuss their experience with 10 quadricuspid valve repairs. No increased perioperative risk is noted by the authors, with excellent long-term results in terms of regurgitation and reoperation on the valve.
Delvin and associates reported the long-term outcomes and quality of life in patients with d-TGA after repair using data from 24 centers of the Congenital Heart Surgeons’ Society (CHSS).
Among 830 neonates operated on between 1985 and 1990, 516 underwent arterial switch, 110 had Mustard operations, 175 Senning procedures, and 29 Rastelli operations. The median duration of follow-up was 24 years, extending to just over 32 years. Survival at 30 years was over 70% for all operations: 86±8% for Rastelli, 81±5% for Mustard, 80±2% for arterial switch, and 70±4% for Senning. The risk of late death was lowest in patients with arterial switch operation. Chest pain and fainting, pacemaker implantation, and unemployment were associated with reduced self-reported health status. Arterial switch patients reported higher functional health status in all domains than did atrial switch patients.
In this article Michael Mack explains his thoughts on the events leading to the death of Neil Armstrong.
Neil Armstrong suffered a tamponade after his pacing wires were removed which led to a series of events leading to his eventual death.
Michael Mack shares his thoughts on the death and his views on the issues it raises, which also raises many important issues for our community with regard to preparedness for complications after heart surgery for which STS guidelines exist but may not yet be fully adopted in some units, and also for surgery in smaller or community hospitals, of which this was an example.
Your thoughts on these important issues will be much appreciated, so please do post your views.
Patient Care and General Interest
The American College of Surgeons introduced a new quality improvement program, the Geriatric Surgery Verification Program, which outlines standards for geriatric surgery with the goal of continuously optimizing care for older adults.
Researchers from Arizona, USA, recommend that the US Preventive Services Task Force expand the eligibility criteria for lung cancer screening to include long-term tobacco quitters and individuals 50-54 years old.
Drugs and Devices
The European Medicines Agency has recommended larotrectinib for the treatment of solid tumors with an NTRK mutation, regardless of the tissue where that tumor is found.
Research, Trials, and Funding
Patients with continuity of care following transcatheter procedures have better outcomes than those with fragmented care, say researchers from North Carolina, USA.
Researchers from Australia are studying a molecule from the venom of a spider that could potentially slow cardiac damage after a heart attack.
Exposure to phtalates, plasticizers that are used in medical devices ranging from blood storage bags and tubing circuits, can affect the electrical properties of rat hearts say researchers from Washington, DC, USA.
White and colleagues retrospectively evaluated the development of postoperative pulmonary venous obstruction for patients undergoing repair of total anomalous pulmonary venous connection (TAPVC) at their institution between 2006 and 2017. Of a total 119 patients, 25 (21%) developed postoperative obstruction. Heterotaxy syndrome, single-ventricle heart disease, concomitant procedures, mixed-type TAPVC, and preoperative obstruction were found to be associated with postoperative obstruction. The authors conclude that these data may help stratify risk for patients with TAPVC.
The Society of Thoracic Surgeons Congenital Heart Surgery Database (STS CHSD) audits the data of 10% of its participants every year. Assessment of the completeness and accuracy of data fields related to demographics, preoperative risk factors, diagnosis, procedure, complications, and mortality is performed. Overman and colleagues summarize the results of the tenth audit of the STS CHSD in this article. The rates of completeness and agreement for general data elements were both over 97%. The rate of completeness for variables in the mortality review was 100%, with a rate of agreement of 99.3%. The authors conclude that the most recently completed STS CHSD audit shows a very high level of completeness and accuracy of data variables, highlighting that this is true for variables that are most germane to outcomes measurement.
This article addresses the controversy surrounding the optimal annular stabilization technique following valve sparing root reconstruction (VSRR) and the lack of comprehensive imaging data in the evaluation of the natural history of aortic root graft geometry, valve competency, and prognosis postreconstruction. Seventy consecutive patients were prospectively enrolled between 2008 and 2017 (mean age 56.4 ± 16.4 years, 19.7% women) for VSRR. Dacron aortic annuloplasty reconstruction was found to be stable over time, without the need for external or internal stabilization. Computed tomography imaging was found to be more reliable than echocardiographic images, although given the noted stability, the authors conclude that it was of little utility.
In this experimental study on segmental artery coil embolization, the authors examined the optimal occlusion pattern to reduce the risk of spinal cord ischemia during thoracoabdominal aortic repair. Von Aspern and colleagues found that staged regional occlusion, with coiling of lumbar arteries first, leads to better perfusion recovery, no neurological deficits, and no cord tissue damage.
In this editorial, Ikonomidis et al not only describe the challenges but also provide specific actionable steps towards improving the retention as well as clinical, academic, and personal success of cardiothoracic surgeon-scientists.
- High clinical, academic, and administrative demands
- Steep competition for extramural funding
- Lack of protected time
- Lack of institutional and departmental support
Action plan includes:
- Lead by example, formal training, mentorship and institutional support
- Institute faculty start-up/support plans including funding and laboratory space that is readily accessible and locally available
- Implement protected paid time for research that is truly protected from clinical duties
- Make research productivity financially incentivized and recognized. Incorporate research productivity into the compensation plan and promotion metrics
- Disseminate opportunities