ALERT!
This site is not optimized for Internet Explorer 8 (or older).
Please upgrade to a newer version of Internet Explorer or use an alternate browser such as Chrome or Firefox.
Journal and News Scan
In this study, the authors compared the long-term outcomes of patients who underwent left atrial appendage closure during mitral repair with those who did not, specifically in patients without atrial fibrillation (AF). The analysis included 10,810 patients from a large US national registry who underwent isolated mitral repairs. Of these, 1,875 (17 percent) received closure, while 8,935 (83 percent) did not. Propensity score matching was performed based on baseline characteristics. The primary outcome of any stroke or thromboembolism was compared between matched groups, with death considered as a competing risk. All-cause mortality was also compared.
Propensity matching yielded 1,875 well-matched patient pairs (mean age: 71 years, 45 percent female, median CHA2DS2-Vasc score 3.0). New post-operative AF was more common in the closure group (45 percent vs 38.4 percent, p<0.01). There was no difference in 30-day mortality (1.2 percent vs 1.1 percent, p=0.88). The closure group demonstrated a reduction in stroke and thromboembolism over five years (6.4 percent vs 8.3 percent, HR: 0.74, 95 percent CI: 0.57-0.96, p=0.023). However, there was no difference in five-year survival rates (91 percent vs 91 percent, HR: 0.99, 95 percent, CI: 0.80-1.23, p=0.95).
The authors concluded that left atrial appendage closure at the time of isolated mitral repair in patients without AF may be associated with an increased incidence of postoperative AF, but it also appears to reduce the risk of late stroke and thromboembolism compared to mitral repair alone.
In a large cohort of 632 patients who underwent “true redo root" surgery (reoperative aortic root surgery after a previous aortic root procedure), the indications for endocarditis and the presence of a previous prosthetic aortic root graft increased the complexity of the procedure and the perioperative course; however, it did not impact the operative mortality. Total time on cardiopulmonary bypass (CPB) and the necessity for ECMO insertion post-pump were identified as independent risk factors for operative mortality. True redo root procedures can be technically demanding and require thorough preoperative assessment, careful planning, and meticulous technique for optimal outcomes. The published report includes a case video presentation to highlight the technical aspects of true redo aortic root procedure.
This article summarizes the most important issues and recommendations regarding the anatomy and physiology of tetralogy-like lesions, including diagnosis prior to medical, interventional, or surgical intervention; the timing and types of interventions; management of high-risk patients; and the need for future interventions in a subset of patients. The full versions of the original guidelines are reprinted in the supplement, providing a more comprehensive overview and enabling a more detailed approach to tetralogy and its variants.
Low-Dose Warfarin With a Novel Mechanical Aortic Valve: Interim Registry Results at 5-Year Follow-Up
This study evaluated the safety of low-dose warfarin (target INR 1.8) combined with daily aspirin (75 100 mg) after On-X mechanical aortic valve implantation. The results showed that the composite rate of major bleeding, valve thrombosis, and thromboembolism was significantly lower in the low-dose warfarin group (1.83 percent) compared to the standard-dose warfarin group (5.39 percent), with reductions in major bleeding and total bleeding by 87 percent and 71 percent, respectively. There was no increase in thromboembolic events, and the outcomes were consistent regardless of home or clinic monitoring. These interim findings support the continued safe use of low-dose warfarin and aspirin as a safe anticoagulation strategy for patients with an On-X valve at five years.
This study evaluated the long-term outcomes of the Ross procedure in neonates and infants with aortic valve pathology demonstrating good post-discharge survival and minimal need for reintervention. Neoaortic dilatation initially peaked but normalized over time, with a high rate of freedom from moderate or greater neoaortic regurgitation (86 percent at 15 years). These findings suggest that the Ross procedure may be a viable option for neonates and infants with aortic valve disease, offering durable outcomes and low rates of autograft reintervention.
This study investigated the initial experience of two cardiac centers starting their robotic programs evaluating the impact of previous minimally invasive mitral valve surgery (MIMVS) experience on the learning curve. A retrospective analysis was performed on the first consecutive cases using the robotic surgical platform at two European centers, with Center 1 transitioning from conventional surgery and Center 2 transitioning from minithoracotomy MIMVS. The learning process was evaluated using surgical times and a combined primary outcome that included relevant intra- and postoperative results, with the first 62 patients from each center included in the analysis. The turning point at the end of the learning phase was detected at the 60th case in Center 1 and at the 50th in Center 2. Regarding surgical time, the learning curve was steeper in Center 1, with both cardiopulmonary bypass and cross-clamp times overcoming the learning phase after 32 cases, as compared to 16 cases in Center 2.
This study assessed the impact of preoperative airflow limitation, stratified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages, on outcomes after open thoracoabdominal aortic aneurysm (TAAA) repair. Patients with chronic obstructive pulmonary disease (COPD) exhibited a higher incidence of pulmonary complications, operative mortality, and adverse events compared to those without COPD, with worsening GOLD severity independently associated with operative death and adverse events. The findings suggest that preoperative risk stratification using GOLD stages can help identify high-risk patients and optimizing their respiratory function may improve outcomes following TAAA repair.
The authors aimed to explore the applicability of the benefits of early mobility and ambulation for patients receiving extracorporeal membrane oxygenation (ECMO). This single-center preintervention, post-intervention review, performed at a high-volume center found that 13 out of 46 (28 percent) patients who met safety criteria ambulated from January through March 2021, compared to 14 out of 147 (10 percent) in historical controls. The authors note important considerations for devising similar protocols given the limited evidence available to date. Strategies employed by the interprofessional team included mobility discussions during rounds, the development of an ambulation safety checklist, clear expectations for providers during ambulation, and documentation to evaluate tolerance. Through standardized assessment and protocol intervention, progressive ambulation can be safely offered to some patients receiving ECMO.
This meta-analysis compares different lung volume reduction techniques for patients with severe emphysema. Analyzing data from 25 randomized controlled trials with 4,283 patients, the study found that lung volume reduction surgery (LVRS) provided the most significant improvement in pulmonary function, exercise capacity, and quality of life, although it was associated with an increased risk of mid-term mortality. Among the bronchoscopic options, endobronchial valves (EBV) and endobronchial coils (EBC) showed moderate efficacy in improving lung function but also carried risks, including pneumothorax and a slight increase in mortality with EBV.
This study provides an evidence-based comparison of surgical and bronchoscopic lung volume reduction strategies, thereby helping to refine patient selection and guide clinical decisions to optimize outcomes in emphysema management.
This prospective randomized trial assessed whether noninvasive ventilation (NIV) before and after cardiac surgery reduces the incidence of acute pulmonary and cardiac failure in high-risk patients. A total of 216 adult patients at risk of postoperative complications were assigned to either NIV for five days pre- and post-surgery or to standard care alone. The primary outcome was the occurrence of cardio-respiratory failure within one month post-surgery. Results showed that 55.1 percent of the NIV group experienced cardiopulmonary failure, compared to 79.8 percent in the standard care group, with NIV significantly reducing the risk (RR 0.69, p<0.001). The benefit persisted at three months; however, there was no difference in intubation rates or ICU stay duration between the two groups. The use of NIV before and after cardiac surgery could effectively lower the rate of cardiopulmonary failure in high-risk patients.