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Journal and News Scan

Source: American Journal of Cardiovascular Drugs
Author(s): Liye Shi, Ling Chen, Guoxian Qi, Wen Tian, Shijie Zhao

An interesting meta-analysis discouraging perhaps the use of this KATP modulator, especially after surgical revascularization where optimization of serum potassium is generally sought.

Source: The Dartmouth National Implementation Science Program
Author(s): Jessica Luc

Dartmouth-Hitchcock Heart and Vascular Center, through support from the National Institutes of Health and the Cardiothoracic Surgical Trials Network, announces a call for applications for the Dartmouth National Implementation Science Program (NISP) Scholar in cardiothoracic surgery – an innovative translational research program designed to train the next generation of clinical investigators. The program can be completed during residency and particularly seeks applications from women and underrepresented minorities. More information on the program and application materials can be found at:  Applications are due by October 1, 2019.

Source: JAMA Network
Author(s): Bobak J. Mortazavi, Emily M. Bucholz, Nihar R. Desai, Chenxi Huang, Jeptha P. Curtis, Frederick A. Masoudi, Richard E. Shaw, Sahand N. Negahban, Harlan M. Krumholz

Using data from more than 3.3 million patients in the NCDR CathPCI Registry, researchers used machine learning to develop an algorithm that predicts post-PCI major bleeding with a C-statistic of 0.82.  

Source: Journal of the American College of Cardiology
Author(s): Tirone E. David, Carolyn M. David, Wendy Tsang, Myriam Lafreniere-Roula, Cedric Manlhiot

In an era of increased use of MitraClip, surgical mitral valve repair still offers a durable solution.  Tirone David and colleages report 1,234 consecutive patients who had mitral valve repair with 20 year follow-up.  

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Ruoyu Zhang, Thomas Kyriss, Jürgen Dippon, Enole Boedeker, Godehard Friedel

Zhang and colleagues examined serum biomarker levels in patients undergoing a lobectomy using video-assisted thoracic surgery. Among 626 patients, they found that preoperative serum LDH was an independent predictor of 90-day cardiopulmonary complications. The authors recommend including LDH measurements in the risk assessment process prior to major lung resection.

Source: The Annals of Thoracic Surgery
Author(s): Matthew Egyud, Mohamedtaki Tejani, Arjun Pennathur, James Luketich, Praveen Sridhar, Emiko Yamada, Anders Ståhlberg, Stefan Filges, Paul Krzyzanowski, Jennifer Jackson, Irina Kalatskaya, Wei Jiao, Gradon Nielsen, Zhongren Zhou, Virginia Litle, Lincoln Stein, Tony Godfrey

Egyud and colleagues evaluated plasma levels of circulating tumor (ct)DNA in patients with esophageal adenocarcinoma, ranging from stage I to stage IV. The quantity of ctDNA and likelihood of ctDNA detection was greater at later stages, suggesting that it may be challenging to use for early-stage diagnosis. However, changes in ctDNA levels were indicative of response to therapy and recurrence, and the authors conclude that they may serve as a dynamic biomarker to monitor a patient’s response to treatment.

Source: The Journal of Thoracic and Cardiovascular Surgery
Author(s): Francis D. Pagani

Excellent and brief summary of the debate on functional mitral regurgitation on mechanical support.

Source: The New England Journal of Medicine
Author(s): Julio A. Panza, Alicia M. Ellis, Hussein R. Al-Khalidi, Thomas A. Holly, Daniel S. Berman, Jae K. Oh, Gerald M. Pohost, George Sopko, Lukasz Chrzanowski, Daniel B. Mark, Tomasz Kukulski, Liliana E. Favaloro, Gerald Maurer, Pedro S. Farsky, Ru-San Tan, Federico M. Asch, Eric J. Velazquez, Jean L. Rouleau, Kerry L. Lee, Robert O. Bonow

A robust RCT that denies association of nuclear CT-defined myocardial viability and long-term benefit from surgical coronary revascularisation. It is worth following the discussion this manuscript is certain to generate..

Source: The Annals of Thoracic Surgery
Author(s): Tara R. Semenkovich, Melanie Subramanian, Yan Yan, Wayne L. Hofstetter, Arlene M. Correa, Stephen D. Cassivi, Matthew L. Inra, Brendon M. Stiles, Nasser K. Altorki, Andrew C. Chang, Alexander A. Brescia, Gail E. Darling, Frances Allison, Stephen R. Broderick, Eric W. Etchill, Felix G. Fernandez, Ray K. Chihara, Virginia R. Litle, Juan A. Muñoz-Largacha, Benjamin D. Kozower, Varun Puri, Bryan F. Meyers

In this multiinstitutional retrospective study, administration of adjuvant chemotherapy for patients with persistent nodal disease after induction therapy and esophagectomy was associated with improved survival.

Source: Journal of Thoracic Oncology
Author(s): Daniel Shepshelovich, Wei Xu, Lin Lu, Aline Fares, Ping Yang, David Christiani, Jie Zhang, Kouya Shiraishi, Brid M. Ryan, Chu Chen, Ann G. Schwartz, Adonina Tardon, Xifeng Wu, Matthew B. Schabath, M. Dawn Teare, Loic Le Marchand, Zuo-Feng Zhang, John K. Field, Hermann Brenner, Nancy Diao, Juntao Xie, Takashi Kohno, Curtis C. Harris, Angela S. Wenzlaff, Guillermo Fernandez-Tardon, Yuanqing Ye, Fiona Taylor, Lynne R. Wilkens, Michael Davies, Yi Liu, Matt J. Barnett, Gary E. Goodman, Hal Morgenstern, Bernd Holleczek, M. Catherine Brown, Geoffrey Liu

This study of over 25,000 pts from the International Lung Cancer Consortium identified underweight and severly obese patients as having poorer survival than others, whereas a survival advantage was evident among patients who were overweight or mildly obese.  Decreased BMI (wt loss) was associated with poorer outcomes across all BMI categories.