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Journal and News Scan

Source: Circulation Research
Author(s): Floriana M Farina, Ignacio Fernando Hall, Simone Serio, Stefania Maria Zani, Montserrat Climent, Nicolò Salvarani, Pierluigi Carullo, Efrem Civilini, Gianluigi Condorelli, Leonardo Elia , Manuela Quintavalle

Interesting to follow up the translational potential of this rodent-model of carotid intimal re-hyperplasia/stenosis.

Source: JAMA Cardiology
Author(s): Shaobo Shi, Mu Qin, Bo Shen, Yuli Cai, Tao Liu, Fan Yang, Wei Gong, Xu Liu, Jinjun Liang, Qinyan Zhao, He Huang, Bo Yang, Congxin Huang

In a cohort of 416 patients hospitalized with COVID-19, nearly 20% had elevated troponins indicating myocardial injury.  These patients also had a host of other serum and radiographic abnormalities, were older, had more comorbidities, and more often required ventilatory support.  Their mortality rate was 51% compared to 4.5% for other hospitalized patients.  Elevated troponins were an independent predictor of mortality (HR 4.26).

Source: New England Journal of Medicine
Author(s): Ezekiel J. Emanuel, Govind Persad, Ross Upshur, Beatriz Thome, Michael Parker, Aaron Glickman, Cathy Zhang, Connor Boyle, Maxwell Smith, James P. Phillips

A frank, eye opening discussion with specific recommendations about allocating scarce resources in a time of pandemic.

Source: New England Journal of Medicine
Author(s): Robert D. Truog, Christine Mitchell, George Q. Daley

A thoughtful commentary about the need for a triage committee to determine the optimal allocation of ventilators in a time of competing needs, and how these determinations are best communicated to caregivers and families.

Source: Journal of Critical Care
Author(s): Andrea Cortegiania, Giulia Ingoglia, Mariachiara Ippolitoa, Antonino Giarratanoa, Sharon Einavb

This is an interesting systematic review looking at the evidence so far for chrloroquine for COVID. it is a fast moving field but this cheap option to treat coronavirus may soon become accepted for treatment once the studies have been fully evaluated. 

Source: Canadian Journal of Anesthesia
Author(s): Lian Kah Ti, Lin Stella Ang, Theng Wai Foong, Bryan Su Wei Ng

Succinct recommendations for the management of COVID-19 cases in the operating room.  Includes infographic outlining comprehensive operating room workflow, detailing the roles and responsibilities of each OR team member.

Source: The Lancet
Author(s): Michael A Matthay, J Matthew Aldrich, Jeffrey E Gotts

A succinct comment with a wealth of up-to-date references vis-a-vis the SARS-CoV-2 pandemic.

Author(s): John P.A. Ioannidis

Interesting input from a Stanford expert on the hottest topic on the planet at the moment.

Source: STAT
Author(s): Susie A. Han and Valerie Gutmann Koch

The authors describe a thoughtful process for resource utilization in the setting of competing needs that optimizes survival for a popultion. Examples of existing guidelines are provided.

Source: Imperial College COVID-19 Response Team
Author(s): Neil M Ferguson, Daniel Laydon, Gemma Nedjati-Gilani, Natsuko Imai, Kylie Ainslie, Marc Baguelin, Sangeeta Bhatia, Adhiratha Boonyasiri, Zulma Cucunubá, Gina Cuomo-Dannenburg, Amy Dighe, Ilaria Dorigatti, Han Fu, Katy Gaythorpe, Will Green, Arran Hamlet, Wes Hinsley, Lucy C Okell, Sabine van Elsland, Hayley Thompson, Robert Verity, Erik Volz, Haowei Wang, Yuanrong Wang, Patrick GT Walker, Caroline Walters, Peter Winskill, Charles Whittaker, Christl A Donnelly, Steven Riley, Azra C Ghani on behalf of the Imperial College COVID-19 Response Team.

This important paper is the modeling that the UK has based its advice on.